Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase - Wikidata - awgldk - TriplyDB

Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

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Transition-state inhibitors of purine salvage and other prospective enzyme targets in malaria Structure-Based Design of Novel Pyrimido[4,5-c]pyridazine Derivatives as Dihydropteroate Synthase Inhibitors with Increased Affinity The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase Identification and characterization of an allosteric inhibitory site on dihydropteroate synthase.Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana Modified 2,4-diaminopyrimidine-based dihydrofolate reductase inhibitors as potential drug scaffolds against Bacillus anthracis Replacing sulfa drugs with novel DHPS inhibitors Sulfonamide-resistant bacteria and their resistance genes in soils fertilized with manures from Jiangsu Province, Southeastern China.Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy.Phytochemical-mediated Protein Expression Profiling and the Potential Applications in Therapeutic Drug Target Identifications.Identification of the Final Two Genes Functioning in Methanofuran Biosynthesis in Methanocaldococcus jannaschii.Uncomplicated Urinary Tract Infections and Antibiotic Resistance-Epidemiological and Mechanistic Aspects Disorder transitions and conformational diversity cooperatively modulate biological function in proteins.Role of Plasmodium vivax Dihydropteroate Synthase Polymorphisms in Sulfa Drug Resistance.Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties.Targeting intracellular p-aminobenzoic acid production potentiates the anti-tubercular action of antifolates.N-acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of Chlamydia trachomatis.Analysis of current antifungal agents and their targets within the Pneumocystis carinii genome.Sulfa and trimethoprim-like drugs - antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors.Utility of the Biosynthetic Folate Pathway for Targets in Antimicrobial Discovery.Antibacterial Antifolates: From Development through Resistance to the Next Generation Design, synthesis, antimicrobial evaluation and molecular docking studies of some new 2,3-dihydrothiazoles and 4-thiazolidinones containing sulfisoxazole.Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.FMNH2-dependent monooxygenases initiate catabolism of sulfonamides in Microbacterium sp. strain BR1 subsisting on sulfonamide antibiotics.Detection of virulence-related genes in Lactococcus garvieae and their expression in response to different conditions.Synthesis, Characterization and Antibacterial Studies of N-(Benzothiazol-2-yl)-4-chlorobenzenesulphonamide and Its Neodymium(III) and Thallium(III) Complexes.Subversion of Metabolic Wasting as the Mechanism for folM-Linked Sulfamethoxazole Resistance.Nanomaterials for alternative antibacterial therapy.4-Substituted thieno[2,3-d]pyrimidines as potent antibacterial agents: Rational design, microwave-assisted synthesis, biological evaluation and molecular docking studies.8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.Exploring the catalytic mechanism of dihydropteroate synthase: elucidating the differences between the substrate and inhibitor.Insights into the drug resistance induced by the BaDHPS mutations: molecular dynamic simulations and MM/GBSA studies.Pathogenic Nocardia cyriacigeorgica and Nocardia nova evolve to resist trimethoprim-sulfamethoxazole by both expected and unexpected pathways.Mutual potentiation drives synergy between trimethoprim and sulfamethoxazole.Genome Sequencing and Comparative Analysis of Stenotrophomonas acidaminiphila Reveal Evolutionary Insights Into Sulfamethoxazole Resistance.Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance Docking Studies in Target Proteins Involved in Antibacterial Action Mechanisms: Extending the Knowledge on Standard Antibiotics to Antimicrobial Mushroom Compounds

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Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

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Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

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Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase

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Antonio M Ferreira

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Donald Bashford

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M Brett Waddell

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Mi-Kyung Yun

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Stephen W White

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Yinan Wu

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Ying Zhao

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Zhenmei Li

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P2860

Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action

Dihydropteroate synthase from Streptococcus pneumoniae: structure, ligand recognition and mechanism of sulfonamide resistance

Structural Studies of Pterin-Based Inhibitors of Dihydropteroate Synthase

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

Crystal Structure of the 6-Hydroxymethyl-7,8-Dihydropterin Pyrophosphokinase•Dihydropteroate Synthase Bifunctional Enzyme from Francisella tularensis

Structure and function of the dihydropteroate synthase from Staphylococcus aureus

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

Inhibition of Pneumocystis carinii dihydropteroate synthetase by sulfa drugs

Resistance to trimethoprim-sulfamethoxazole.

Trimethoprim-sulfamethoxazole revisited.

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