Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
about
When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transitionRND-type drug efflux pumps from Gram-negative bacteria: molecular mechanism and inhibitionRecent advances toward a molecular mechanism of efflux pump inhibitionCrystal structure of AcrB complexed with linezolid at 3.5 Å resolutionDesign, construction, and characterization of a second-generation DARPin library with reduced hydrophobicityStructures of intermediate transport states of ZneA, a Zn(II)/proton antiporterStructure of the AcrAB–TolC multidrug efflux pumpStructural basis for the inhibition of bacterial multidrug exportersStructural basis of RND-type multidrug exportersFunctional relevance of AcrB Trimerization in pump assembly and substrate bindingStructures of Gate Loop Variants of the AcrB Drug Efflux Pump Bound by Erythromycin SubstrateNanobodies as Probes for Protein Dynamics in Vitro and in Cells.Multidrug binding properties of the AcrB efflux pump characterized by molecular dynamics simulations.A data-driven approach to modeling the tripartite structure of multidrug resistance efflux pumps.An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pumpCurrent Advances in Developing Inhibitors of Bacterial Multidrug Efflux Pumpsβ-Lactam selectivity of multidrug transporters AcrB and AcrD resides in the proximal binding pocket.Crystal structure of the Neisseria gonorrhoeae MtrD inner membrane multidrug efflux pump.Crystal structures of the Burkholderia multivorans hopanoid transporter HpnNMolecular mechanism of MBX2319 inhibition of Escherichia coli AcrB multidrug efflux pump and comparison with other inhibitorsRepressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB.Characterization of a novel pyranopyridine inhibitor of the AcrAB efflux pump of Escherichia coliCoupling of remote alternating-access transport mechanisms for protons and substrates in the multidrug efflux pump AcrBAcrB drug-binding pocket substitution confers clinically relevant resistance and altered substrate specificity.Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB.The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.Improving olefin tolerance and production in E. coli using native and evolved AcrB.Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosaTranslocation of Non-Canonical Polypeptides into Cells Using Protective AntigenReversal of the Drug Binding Pocket Defects of the AcrB Multidrug Efflux Pump Protein of Escherichia coli.Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB.Conserved small protein associates with the multidrug efflux pump AcrB and differentially affects antibiotic resistanceTripartite assembly of RND multidrug efflux pumps.Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivativesNa⁺-substrate coupling in the multidrug antiporter norm probed with a spin-labeled substrate.Different functions of MdtB and MdtC subunits in the heterotrimeric efflux transporter MdtB(2)C complex of Escherichia coliEfflux pumps of Gram-negative bacteria: what they do, how they do it, with what and how to deal with them.Design of New Antibacterial Enhancers Based on AcrB's Structure and the Evaluation of Their Antibacterial Enhancement Activity.Some ligands enhance the efflux of other ligands by the Escherichia coli multidrug pump AcrB.Molecular Dynamics Computer Simulations of Multidrug RND Efflux Pumps
P2860
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P2860
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Transport of drugs by the mult ...... are separated by a switch-loop
@ast
Transport of drugs by the mult ...... are separated by a switch-loop
@en
Transport of drugs by the mult ...... are separated by a switch-loop
@nl
type
label
Transport of drugs by the mult ...... are separated by a switch-loop
@ast
Transport of drugs by the mult ...... are separated by a switch-loop
@en
Transport of drugs by the mult ...... are separated by a switch-loop
@nl
prefLabel
Transport of drugs by the mult ...... are separated by a switch-loop
@ast
Transport of drugs by the mult ...... are separated by a switch-loop
@en
Transport of drugs by the mult ...... are separated by a switch-loop
@nl
P2093
P2860
P50
P3181
P356
P1476
Transport of drugs by the mult ...... are separated by a switch-loop
@en
P2093
Hi-jea Cha
Jasmin El-Delik
Jürgen A Bohnert
Klaas M Pos
Markus A Seeger
Markus G Grütter
Thomas Eicher
Winfried V Kern
P2860
P304
P3181
P356
10.1073/PNAS.1114944109
P407
P577
2012-04-10T00:00:00Z