Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity - Wikidata - awgldk - TriplyDB

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

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Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.The enemy within: endogenous retroelements and autoimmune disease Rationale, progress and development of vaccines utilizing STING-activating cyclic dinucleotide adjuvants Structural and Functional Analyses of DNA-Sensing and Immune Activation by Human cGAS The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity DNA sensor cGAS-mediated immune recognition Innate immune recognition of DNA: A recent history International Union of Basic and Clinical Pharmacology. XCVI. Pattern recognition receptors in health and disease Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication Dissecting How CD4 T Cells Are Lost During HIV Infection Role of the HIN domain in regulation of innate immune responses Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity FAM46 proteins are novel eukaryotic non-canonical poly(A) polymerases The N terminus of cGAS de-oligomerizes the cGAS:DNA complex and lifts the DNA size restriction of core-cGAS activity.Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation.Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING Structure-guided reprogramming of human cGAS dinucleotide linkage specificity.The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP The mechanism of double-stranded DNA sensing through the cGAS-STING pathway Mutations in MAB21L2 result in ocular Coloboma, microcornea and cataracts Modified vaccinia virus Ankara triggers type I IFN production in murine conventional dendritic cells via a cGAS/STING-mediated cytosolic DNA-sensing pathway Emerging principles governing signal transduction by pattern-recognition receptors Structural biology of innate immunity.OASes and STING: adaptive evolution in concert Single amino acid change in STING leads to constitutive active signaling.Overlapping Patterns of Rapid Evolution in the Nucleic Acid Sensors cGAS and OAS1 Suggest a Common Mechanism of Pathogen Antagonism and Escape.Elucidating Complicated Assembling Systems in Biology Using Size-and-Shape Analysis of Sedimentation Velocity Data.Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling.PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6.Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing.The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion.

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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

http://www.wikidata.org/entity/Q27678294

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2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013 թվականի մայիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity

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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity

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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity

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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity

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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity

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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity

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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity

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J.CELREP.2013.05.008

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Structure of Human cGAS Reveal ...... ger Enzymes in Innate Immunity

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Amy Si-Ying Lee

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James M Berger

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Philip J Kranzusch

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P2860

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

A diverse range of gene products are effectors of the type I interferon antiviral response

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

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10.1016/J.CELREP.2013.05.008

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5

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3

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Jennifer Doudna

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236938208

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23707061

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3800681

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