Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown
about
Insights into APC/C: from cellular function to diseases and therapeuticsWrecked regulation of intrinsically disordered proteins in diseases: pathogenicity of deregulated regulatorsAtomic structure of the APC/C and its mechanism of protein ubiquitination.The zinc-binding region (ZBR) fragment of Emi2 can inhibit APC/C by targeting its association with the coactivator Cdc20 and UBE2C-mediated ubiquitylationCryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin LigationA decade of the anaphase-promoting complex in the nervous systemSpatiotemporal regulation of the anaphase-promoting complex in mitosisProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical spaceTowards an integrative structural biology approach: combining Cryo-TEM, X-ray crystallography, and NMR.The N-terminal Region of the Ubiquitin Regulatory X (UBX) Domain-containing Protein 1 (UBXD1) Modulates Interdomain Communication within the Valosin-containing Protein p97.Molecular architecture and mechanism of the anaphase-promoting complexCancer/Testis Antigens: "Smart" Biomarkers for Diagnosis and Prognosis of Prostate and Other CancersIntrinsically disordered proteins in cellular signalling and regulation.RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complexA Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain.biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes.RBR E3-ligases at workUbiquitination in disease pathogenesis and treatment.Measuring APC/C-Dependent Ubiquitylation In Vitro.Structural insights into the catalysis and regulation of E3 ubiquitin ligases.Detection and Analysis of Cell Cycle-Associated APC/C-Mediated Cellular Ubiquitylation In Vitro and In Vivo.Building a Regulatory Network with Short Linear Sequence Motifs: Lessons from the Degrons of the Anaphase-Promoting Complex.Aneuploidy in Cancer and Aging.Digested disorder: Quarterly intrinsic disorder digest (July-August-September, 2013)Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.Bayesian inference of initial models in cryo-electron microscopy using pseudo-atoms.Human papillomavirus type 16 E7 oncoprotein inhibits the anaphase promoting complex/cyclosome activity by dysregulating EMI1 expression in mitosis.Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).Functional Analysis of Human Hub Proteins and Their Interactors Involved in the Intrinsic Disorder-Enriched Interactions.EMI1, a three-in-one ubiquitylation inhibitor.The roles of intrinsic disorder-based liquid-liquid phase transitions in the "Dr. Jekyll-Mr. Hyde" behavior of proteins involved in amyotrophic lateral sclerosis and frontotemporal lobar degeneration.In vivo overexpression of Emi1 promotes chromosome instability and tumorigenesis.EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.
P2860
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P2860
Electron microscopy structure of human APC/CCDH1–EMI1 reveals multimodal mechanism of E3 ligase shutdown
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Electron microscopy structure ...... echanism of E3 ligase shutdown
@ast
Electron microscopy structure ...... echanism of E3 ligase shutdown
@en
Electron microscopy structure ...... echanism of E3 ligase shutdown
@nl
type
label
Electron microscopy structure ...... echanism of E3 ligase shutdown
@ast
Electron microscopy structure ...... echanism of E3 ligase shutdown
@en
Electron microscopy structure ...... echanism of E3 ligase shutdown
@nl
prefLabel
Electron microscopy structure ...... echanism of E3 ligase shutdown
@ast
Electron microscopy structure ...... echanism of E3 ligase shutdown
@en
Electron microscopy structure ...... echanism of E3 ligase shutdown
@nl
P2093
P2860
P921
P3181
P356
P1476
Electron microscopy structure ...... echanism of E3 ligase shutdown
@en
P2093
Amanda Nourse
Brenda A Schulman
Christy R R Grace
Edmond R Watson
Holger Stark
Jeremiah J Frye
Marc A Jarvis
Nicholas G Brown
Richard W Kriwacki
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2593
P577
2013-07-01T00:00:00Z
P5875
P6179
1052234545