Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation
about
Phospholipid--driven gene regulationSteroid receptor coactivators: servants and masters for control of systems metabolismDivergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone ReceptorsCrystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of ActivationDisulfide-Trapping Identifies a New, Effective Chemical Probe for Activating the Nuclear Receptor Human LRH-1 (NR5A2)The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.Identification of a small molecular insulin receptor agonist with potent antidiabetes activity.Antiproliferation activity of a small molecule repressor of liver receptor homolog 1Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programsHaploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.LRH-1-dependent glucose sensing determines intermediary metabolism in liver.Liver receptor homolog-1 (LRH-1): a potential therapeutic target for cancerStructure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket.Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.Structure-based discovery of antagonists of nuclear receptor LRH-1.Biliary Phospholipids Sustain Enterocyte Proliferation and Intestinal Tumor Progression via Nuclear Receptor Lrh1 in mice.Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver diseaseDisentangling biological signaling networks by dynamic coupling of signaling lipids to modifying enzymes.Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex.Phosphatidylcholine's functions beyond that of a membrane brick.Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.Multiple functions and essential roles of nuclear receptor coactivators of bHLH-PAS family.1-Carbon Cycle Metabolites Methylate Their Way to Fatty Liver.Phospholipid regulation of the nuclear receptor superfamily.LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPARγ ligand synthesisHDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions.LRH-1: orphaned, adopted and needed for pregnancy.Solution Nuclear Magnetic Resonance Studies of the Ligand-Binding Domain of an Orphan Nuclear Receptor Reveal a Dynamic Helix in the Ligand-Binding Pocket.Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1
P2860
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P2860
Antidiabetic phospholipid–nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@ast
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@en
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@nl
type
label
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@ast
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@en
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@nl
prefLabel
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@ast
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@en
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@nl
P2093
P2860
P3181
P356
P1476
Antidiabetic phospholipid–nucl ...... holipid-driven gene regulation
@en
P2093
Eric A Ortlund
Janelle L Lauer
Manish C Pathak
Patrick R Griffin
Paul M Musille
William H Hudson
P2860
P2888
P304
532-7, S1-2
P3181
P356
10.1038/NSMB.2279
P577
2012-04-15T00:00:00Z
P5875
P6179
1033309482