Molecular mechanism of ATP binding and ion channel activation in P2X receptors
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The role of purinergic receptors in cancer-induced bone painInsights into the channel gating of P2X receptors from structures, dynamics and small moleculesPurinergic signalling and diabetesTwo open states of P2X receptor channelsExploring the ATP-binding site of P2X receptorsMotifs in the permeation pathway of connexin channels mediate voltage and Ca (2+) sensingSize matters in activation/inhibition of ligand-gated ion channelsP2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disordersPrinciples and properties of ion flow in P2X receptorsEnergy-requiring uptake of prostasomes and PC3 cell-derived exosomes into non-malignant and malignant cells.Characterization of ATPase Activity of P2RX2 Cation ChannelInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsStructural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexesTRPV1 structures in distinct conformations reveal activation mechanismsX-ray structures define human P2X3 receptor gating cycle and antagonist actionDynamics of T-Junction Solution Switching Aimed at Patch Clamp ExperimentsPhysical basis of apparent pore dilation of ATP-activated P2X receptor channelsConductance of P2X4 purinergic receptor is determined by conformational equilibrium in the transmembrane regionLocalization of the gate and selectivity filter of the full-length P2X7 receptorSolution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding.Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating.Imaging P2X4 receptor subcellular distribution, trafficking, and regulation using P2X4-pHluorinPurinergic control of lysenin's transport and voltage-gating propertiesGlycosides from edible sea cucumbers stimulate macrophages via purinergic receptors.Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.Purinergic control of inflammation and thrombosis: Role of P2X1 receptorsCorrelation between urothelial differentiation and sensory proteins P2X3, P2X5, TRPV1, and TRPV4 in normal urothelium and papillary carcinoma of human bladder.Signal transmission within the P2X2 trimeric receptor.P2X4 Receptor Function in the Nervous System and Current Breakthroughs in Pharmacology.Protons and Psalmotoxin-1 reveal nonproton ligand stimulatory sites in chicken acid-sensing ion channel: Implication for simultaneous modulation in ASICs.A selectivity filter at the intracellular end of the acid-sensing ion channel pore.Neuromodulation by extracellular ATP and P2X receptors in the CNS.P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.Mechanical coupling maintains the fidelity of NMDA receptor-mediated currentsRegulation of ATP-gated P2X channels: from redox signaling to interactions with other proteinsGeneral rules for the arrangements and gating motions of pore-lining helices in homomeric ion channels.The recombinant expression systems for structure determination of eukaryotic membrane proteinsNon-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkersThe structural basis of ATP as an allosteric modulator
P2860
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P2860
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
description
2012 nî lūn-bûn
@nan
2012 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@ast
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@en
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@nl
type
label
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@ast
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@en
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@nl
prefLabel
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@ast
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@en
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@nl
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P3181
P356
P1433
P1476
Molecular mechanism of ATP binding and ion channel activation in P2X receptors
@en
P2093
Eric Gouaux
Motoyuki Hattori
P2860
P2888
P304
P3181
P356
10.1038/NATURE11010
P407
P50
P577
2012-05-01T00:00:00Z
P5875
P6179
1030825714