X-ray structures define human P2X3 receptor gating cycle and antagonist action
about
Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.The effect of sinomenine in diabetic neuropathic pain mediated by the P2X3 receptor in dorsal root gangliaA selectivity filter at the intracellular end of the acid-sensing ion channel pore.Structural basis for subtype-specific inhibition of the P2X7 receptor.Structural insights into the nucleotide base specificity of P2X receptors.ATP-Gated P2X3 Receptors Are Specialised Sensors of the Extracellular Environment.On the permeation of large organic cations through the pore of ATP-gated P2X receptors.The P2X7 Receptor-Interleukin-1 Liaison.ATP-induced Ca(2+)-signalling mechanisms in the regulation of mesenchymal stem cell migration.P2X Receptor Activation.P2X receptor-channels in chronic pain pathways.Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase.The P2X7 receptor forms a dye-permeable pore independent of its intracellular domain but dependent on membrane lipid composition.Structural insights into the competitive inhibition of the ATP-gated P2X receptor channelP2X2 Dominant Deafness Mutations Have No Negative Effect on Wild-Type Isoform: Implications for Functional Rescue and in Deafness Mechanism.The Molecular Determinants of Small-Molecule Ligand Binding at P2X Receptors.Purinergic drug targets for gastrointestinal disorders.PyContact: Rapid, Customizable, and Visual Analysis of Noncovalent Interactions in MD Simulations.The P2X7 Receptor.Intersubunit physical couplings fostered by the left flipper domain facilitate channel opening of P2X4 receptors.The ASIC3/P2X3 cognate receptor is a pain-relevant and ligand-gated cationic channel.Structure of the mechanically activated ion channel Piezo1.Druggable negative allosteric site of P2X3 receptors.
P2860
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P2860
X-ray structures define human P2X3 receptor gating cycle and antagonist action
description
2016 nî lūn-bûn
@nan
2016 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2016 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
name
X-ray structures define human P2X3 receptor gating cycle and antagonist action
@ast
X-ray structures define human P2X3 receptor gating cycle and antagonist action
@en
X-ray structures define human P2X<sub>3</sub> receptor gating cycle and antagonist action
@nl
type
label
X-ray structures define human P2X3 receptor gating cycle and antagonist action
@ast
X-ray structures define human P2X3 receptor gating cycle and antagonist action
@en
X-ray structures define human P2X<sub>3</sub> receptor gating cycle and antagonist action
@nl
prefLabel
X-ray structures define human P2X3 receptor gating cycle and antagonist action
@ast
X-ray structures define human P2X3 receptor gating cycle and antagonist action
@en
X-ray structures define human P2X<sub>3</sub> receptor gating cycle and antagonist action
@nl
P2093
P2860
P356
P1433
P1476
X-ray structures define human ...... ng cycle and antagonist action
@en
P2093
Mrinal Shekhar
Steven E Mansoor
Wout Oosterheert
P2860
P2888
P356
10.1038/NATURE19367
P407
P577
2016-09-14T00:00:00Z
P6179
1041236374