Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol - Wikidata - awgldk - TriplyDB

Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

http://www.wikidata.org/entity/Q27679036

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Structural Studies of G Protein-Coupled Receptors Biased and g protein-independent signaling of chemokine receptors Large-scale production and protein engineering of G protein-coupled receptors for structural studies New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors Molecular Evolution and Functional Divergence of Trace Amine-Associated Receptors Biophysical Fragment Screening of the β 1 -Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design Structural Features for Functional Selectivity at Serotonin Receptors Insights into congenital stationary night blindness based on the structure of G90D rhodopsin The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor Generic GPCR residue numbers - aligning topology maps while minding the gaps Structural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congeners Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes.The power of mass spectrometry in structural characterization of GPCR signaling.Compound activity prediction using models of binding pockets or ligand properties in 3D.Simulations of biased agonists in the β(2) adrenergic receptor with accelerated molecular dynamics.Structure-function of the G protein-coupled receptor superfamily.Allosteric sodium in class A GPCR signaling Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors.Functional Characterization of a Novel Series of Biased Signaling Dopamine D3 Receptor Agonists.What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?Structural features of β2 adrenergic receptor: crystal structures and beyond.A mechanistic role of Helix 8 in GPCRs: Computational modeling of the dopamine D2 receptor interaction with the GIPC1-PDZ-domain.Uncovering the triggers for GPCR activation using solid-state NMR spectroscopy.Identification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae.Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound β1-Adrenergic Receptor.Advances in receptor conformation research: the quest for functionally selective conformations focusing on the β2-adrenoceptor How Can Mutations Thermostabilize G-Protein-Coupled Receptors?Carvedilol binding to β2-adrenergic receptors inhibits CFTR-dependent anion secretion in airway epithelial cells The role of kinetic context in apparent biased agonism at GPCRs.Optimising the combination of thermostabilising mutations in the neurotensin receptor for structure determination.Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations.Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1).Thermostabilization of the β1-adrenergic receptor correlates with increased entropy of the inactive state.A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor.Amino acid conservation and interactions in rhodopsin: probing receptor activation by NMR spectroscopy.The importance of interactions with helix 5 in determining the efficacy of β-adrenoceptor ligands.X-ray structural information of GPCRs in drug design: what are the limitations and where do we go?Molecular modeling of vasopressin receptor and in silico screening of V1b receptor antagonists.

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Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

http://www.wikidata.org/entity/Q27679036

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2012 nî lūn-bûn

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2012 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2012年の論文

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Crystal Structures of a Stabil ...... ists Bucindolol and Carvedilol

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J.STR.2012.03.014

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Crystal Structures of a Stabil ...... ists Bucindolol and Carvedilol

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Andrew G W Leslie

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Patricia C Edwards

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A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor

Structure of an agonist-bound human A2A adenosine receptor

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

Structure and function of an irreversible agonist-β(2) adrenoceptor complex

Crystal structure of the β2 adrenergic receptor-Gs protein complex

High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor

MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor

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10.1016/J.STR.2012.03.014

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5

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20

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Christopher G. Tate

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2012-05-09T00:00:00Z

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224948511

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22579251

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crystal structure

structural biology

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3384003

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