A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.
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A new mechanism of allostery in a G protein-coupled receptor dimerBeyond small-molecule SAR: using the dopamine D3 receptor crystal structure to guide drug designChiral Resolution and Serendipitous Fluorination Reaction for the Selective Dopamine D3 Receptor Antagonist BAK2-66Design, synthesis, and structure-activity relationship studies of a series of [4-(4-carboxamidobutyl)]-1-arylpiperazines: insights into structural features contributing to dopamine D3 versus D2 receptor subtype selectivity.Targeting the dopamine D3 receptor: an overview of drug design strategies.What can crystal structures of aminergic receptors tell us about designing subtype-selective ligands?Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands.Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonistsIdentifying Medication Targets for Psychostimulant Addiction: Unraveling the Dopamine D3 Receptor Hypothesis.Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity.High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice.Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptorsOptical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions.Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors.Synthesis, Biological, and Computational Evaluation of Substituted 1-(2-Methoxyphenyl)-4-(1-phenethylpiperidin-4-yl)piperazines and 1-(2-Methoxyphenyl)-4-[(1-phenethylpiperidin-4-yl)methyl]piperazines as Dopaminergic Ligands.
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A single glycine in extracellular loop 1 is the critical determinant for pharmacological specificity of dopamine D2 and D3 receptors.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 23 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A single glycine in extracellu ...... dopamine D2 and D3 receptors.
@en
A single glycine in extracellu ...... dopamine D2 and D3 receptors.
@nl
type
label
A single glycine in extracellu ...... dopamine D2 and D3 receptors.
@en
A single glycine in extracellu ...... dopamine D2 and D3 receptors.
@nl
prefLabel
A single glycine in extracellu ...... dopamine D2 and D3 receptors.
@en
A single glycine in extracellu ...... dopamine D2 and D3 receptors.
@nl
P2093
P2860
P356
P1476
A single glycine in extracellu ...... f dopamine D2 and D3 receptors
@en
P2093
Amy Hauck Newman
Ashwini Banala
Eric Trinquet
Lihua Duan
Mayako Michino
Prashant Donthamsetti
Thijs Beuming
Thomas Roux
P2860
P304
P356
10.1124/MOL.113.087833
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2013-09-23T00:00:00Z