Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam - Wikidata - awgldk - TriplyDB

Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam

Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam

http://www.wikidata.org/entity/Q27679174

about

Structural Origins of Oxacillinase Specificity in Class D -Lactamases Crystal Structure of Carbapenemase OXA-58 from Acinetobacter baumannii The structure of a doripenem-bound OXA-51 class D β-lactamase variant with enhanced carbapenemase activity Structural basis for carbapenem-hydrolyzing mechanisms of carbapenemases conferring antibiotic resistance A fluorescent carbapenem for structure function studies of penicillin-binding proteins, β-lactamases, and β-lactam sensors.Structural basis of activity against aztreonam and extended spectrum cephalosporins for two carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.Structural Basis for Enhancement of Carbapenemase Activity in the OXA-51 Family of Class D β-Lactamases.Class D β-lactamases do exist in Gram-positive bacteria.Clinical Variants of the Native Class D β-Lactamase of Acinetobacter baumannii Pose an Emerging Threat through Increased Hydrolytic Activity against Carbapenems Kinetic characterization of GES-22 β-lactamase harboring the M169L clinical mutation.OXA β-lactamases.Acquired Class D β-Lactamases.Structural basis for the extended substrate spectrum of AmpC BER and structure-guided discovery of the inhibition activity of citrate against the class C β-lactamases AmpC BER and CMY-10.Activity of the β-Lactamase inhibitor LN-1-255 against carbapenem-hydrolyzing class D β-lactamases from Acinetobacter baumannii.Exploring the potential of boronic acids as inhibitors of OXA-24/40 β-lactamase.Active-Site Plasticity Is Essential to Carbapenem Hydrolysis by OXA-58 Class D β-Lactamase of Acinetobacter baumannii.OXA-372, a novel carbapenem-hydrolysing class D β-lactamase from a Citrobacter freundii isolated from a hospital wastewater plant.Bactericidal activity, absence of serum effect, and time-kill kinetics of ceftazidime-avibactam against β-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa.Common clinical substitutions enhance the carbapenemase activity of OXA-51-like class D β-lactamases from Acinetobacter spp.Deciphering multifactorial resistance phenotypes in Acinetobacter baumannii by genomics and targeted label-free proteomics.Multiple substitutions lead to increased loop flexibility and expanded specificity in Acinetobacter baumannii carbapenemase OXA-239.Antimicrobial resistance (AMR) nanomachines-mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation.

P2860

Q27680475-1F8CC853-EF01-468C-BE0F-88991B5F09C4 Q27681472-3F348AED-01AA-42A8-8198-1619BEAA6D1B Q27728076-DE79B680-9997-4F56-ADB4-4A82E026DAAA Q28084628-5E9810AD-5150-4788-9737-4AF4E4F860B3 Q34206986-F04FF965-5E40-44B4-A2D3-FC698C8E0195 Q35765638-B4E7886C-7020-43B8-BDDC-108DDFDD32B5 Q35987600-8A71E0C4-74C9-4C39-82AA-7FCE5D616222 Q36386436-D2808611-305D-4E52-9726-4E295D05FB0E Q37287767-518476F2-94D6-4865-B1ED-271E3EF52332 Q37409854-4F8C7638-F982-4FEC-9FB0-82BEA01A8FCA Q38201699-EC860754-490A-4150-88A5-BC3F4E894D16 Q38792886-27A5A39F-19E8-4757-BCC7-D5179D27921E Q39528655-DFC7F060-FC38-4CA6-9984-E99641C55CD2 Q40083229-CD59CBAB-0F4D-42C7-A142-BB9658433ABB Q40402495-1A62441C-3409-40E1-940D-A6ED14697B9D Q40439699-E5ADA7F2-D1C1-496B-B9CF-7FED188521A2 Q40781496-37546A55-4C77-431F-BB5B-FCCF46F466EB Q42797037-CD945A73-0FBD-41C2-958C-1EB86F0F03CD Q43045762-6376502F-46EE-414C-AFEB-AE1287983284 Q47273518-D7BCD761-B447-4028-BA33-2E084B5F0C6F Q47305062-7417282E-FC68-4A90-94D5-628B48726DE5 Q52360303-2E61ED41-2028-4E1D-9807-7988F4B1A605

P2860

Structures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and Aztreonam

http://www.wikidata.org/entity/Q27679174

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@ast

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@en

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@nl

type

label

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@ast

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@en

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@nl

prefLabel

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@ast

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@en

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@nl

P1433

Q27679174-B931E4B5-BE55-459D-AA4F-5B65C032DF2B

P1476

Q27679174-E3AD19DF-69DD-48B6-91E1-3679DE8531E1

P2093

Q27679174-002EA1A1-F1DC-4A79-AB79-BF18180FF23A

Q27679174-83A6E64D-9EFF-4433-B5BE-7F29CDEF09F7

Q27679174-8C09B0FF-FF1C-4802-9616-2E8A2ECD1A4B

Q27679174-AEB84241-0A07-48AC-877D-094EC917F4C3

Q27679174-B9DF20C3-0950-49BC-8C4F-6A2CA5339719

Q27679174-F2B76C5B-43C1-4632-ACB2-842753A78125

P2860

Q27679174-0257E269-4C5D-41D3-B5D0-58B5A248C843

Q27679174-0377CEE8-4ED6-417F-8D97-2ADECAFB65D8

Q27679174-0549B5C4-D88D-4788-949A-3A5C4EBB1FCA

Q27679174-06F2768A-60C1-4FEA-AAC0-72F088522D7D

Q27679174-081E74D4-1ACF-452B-B22E-6934693693DA

Q27679174-0C880C86-F7F5-443C-B754-2A279EE31BF9

Q27679174-1BB6F51A-A67B-4CE6-9AF9-4F94AE85014C

Q27679174-3445C1D1-52CD-4BDB-9E40-7F19F85237E3

Q27679174-391537E4-0870-443B-8098-E3801D18E7FB

Q27679174-3B33428E-3EA3-405D-8F11-7B9F977822C6

P304

Q27679174-F2747310-984C-4C1C-9F3C-F9CF91F585F9

P31

Q27679174-E1B4D019-5124-45CD-B790-AFB6D582F369

P356

Q27679174-F387276B-EA93-4CE5-9C91-5ECFF72A23BC

P407

Q27679174-7F689B14-7D3F-4E00-A4FE-FF6A09730FB8

P433

Q27679174-B64B3AD8-20CA-4349-A3F7-CD6171623F5A

P478

Q27679174-A6D47750-6FFE-417D-91AA-FAE5DCA61514

P50

Q27679174-9B873637-587D-4B3F-B1D9-A07D7605E67A

P577

Q27679174-96F6AE5A-286F-47D6-9DEA-1A8A2363A2A2

P698

Q27679174-9E88A43B-1992-450F-BBAF-BBF6BE9279A2

P921

Q27679174-8603A219-1F64-444F-A350-37631F255D1B

P932

Q27679174-D0542BA5-35F5-41E9-8B28-B5CC41C8BE91

P356

P1433

Antimicrobial Agents and Chemotherapy

P1476

Structures of the Class D Carb ...... Cephalosporins, and Aztreonam

@en

P2093

Cynthia M June

http://www.w3.org/2001/XMLSchema#string

David A Leonard

http://www.w3.org/2001/XMLSchema#string

Kip-Chumba J Kaitany

http://www.w3.org/2001/XMLSchema#string

Maddison E Ramey

http://www.w3.org/2001/XMLSchema#string

Neil V Klinger

http://www.w3.org/2001/XMLSchema#string

Rachel A Powers

http://www.w3.org/2001/XMLSchema#string

P2860

A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

MolProbity: all-atom structure validation for macromolecular crystallography

Crystal structure of the carbapenemase OXA-24 reveals insights into the mechanism of carbapenem hydrolysis

Structure of the extended-spectrum class C beta-lactamase of Enterobacter cloacae GC1, a natural mutant with a tandem tripeptide insertion

Crystal structure of the class D beta-lactamase OXA-10

Crystal structures of the class D beta-lactamase OXA-13 in the native form and in complex with meropenem

Critical involvement of a carbamylated lysine in catalytic function of class D -lactamases

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

Ultrahigh resolution structure of a class A beta-lactamase: on the mechanism and specificity of the extended-spectrum SHV-2 enzyme

Genetic and Structural Characterization of an L201P Global Suppressor Substitution in TEM-1 β-Lactamase

P304

4848-55

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/AAC.00762-13

http://www.w3.org/2001/XMLSchema#string

P407

P433

10

http://www.w3.org/2001/XMLSchema#string

P478

57

http://www.w3.org/2001/XMLSchema#string

P50

Robert A Bonomo

P577

2013-10-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

23877677

http://www.w3.org/2001/XMLSchema#string

P921

carbapenem antibiotic

P932

3811470

http://www.w3.org/2001/XMLSchema#string