about
"Stormy waters ahead": global emergence of carbapenemasesTopical triple-antibiotic ointment as a novel therapeutic choice in wound management and infection prevention: a practical perspectiveExtended-spectrum beta-lactamases: a clinical update10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of AmericaOutbreak of colistin-resistant, carbapenem-resistant Klebsiella pneumoniae in metropolitan Detroit, MichiganCarbapenems: past, present, and futureThree decades of beta-lactamase inhibitorsSulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamaseExtended-spectrum beta-lactamases in Klebsiella pneumoniae bloodstream isolates from seven countries: dominance and widespread prevalence of SHV- and CTX-M-type beta-lactamasesNew β-Lactamase Inhibitors in the ClinicSalvage microbiology: opportunities and challenges in the detection of bacterial pathogens following initiation of antimicrobial treatmentUltrahigh resolution structure of a class A beta-lactamase: on the mechanism and specificity of the extended-spectrum SHV-2 enzymeInhibition of class A and class C beta-lactamases by penems: crystallographic structures of a novel 1,4-thiazepine intermediateTazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structureCrystal Structure of KPC-2: Insights into Carbapenemase Activity in Class A β-Lactamases † , ‡Inhibition of Class A β-Lactamases by Carbapenems: Crystallographic Observation of Two Conformations of Meropenem in SHV-1Computational Redesign of the SHV-1 β-Lactamase/β-Lactamase Inhibitor Protein InterfaceStrategic Design of an Effective -Lactamase Inhibitor: LN-1-255, A 6-ALKYLIDENE-2'-SUBSTITUTED PENICILLIN SULFONEStructural and Biochemical Characterization of the Interaction between KPC-2 β-Lactamase and β-Lactamase Inhibitor Protein,The 1.4 Å Crystal Structure of the Class D β-Lactamase OXA-1 Complexed with DoripenemDesign, Synthesis, and Crystal Structures of 6-Alkylidene-2′-Substituted Penicillanic Acid Sulfones as Potent Inhibitors of Acinetobacter baumannii OXA-24 CarbapenemaseNovel Insights into the Mode of Inhibition of Class A SHV-1 -Lactamases Revealed by Boronic Acid Transition State InhibitorsStructures of the Class D Carbapenemase OXA-24 from Acinetobacter baumannii in Complex with DoripenemSpecificity and cooperativity at β-lactamase position 104 in TEM-1/BLIP and SHV-1/BLIP interactionsLigand-Dependent Disorder of the Loop Observed in Extended-Spectrum SHV-Type -LactamaseCrystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamaseStructures of SHV-1 β-Lactamase with Penem and Penam Sulfone Inhibitors That Form Cyclic Intermediates Stabilized by Carbonyl ConjugationDesign and Exploration of Novel Boronic Acid Inhibitors Reveals Important Interactions with a Clavulanic Acid-Resistant Sulfhydryl-Variable (SHV) β-LactamaseCrystal Structures of KPC-2 -Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226Insights into -Lactamases from Burkholderia Species, Two Phylogenetically Related yet Distinct Resistance DeterminantsThe Importance of thetrans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase VariantsStructures of the Class D Carbapenemases OXA-23 and OXA-146: Mechanistic Basis of Activity against Carbapenems, Extended-Spectrum Cephalosporins, and AztreonamCan Inhibitor-Resistant Substitutions in the Mycobacterium tuberculosis -Lactamase BlaC Lead to Clavulanate Resistance?: a Biochemical Rationale for the Use of -Lactam- -Lactamase Inhibitor CombinationsStructural Origins of Oxacillinase Specificity in Class D -Lactamasesβ-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-EnzymePenam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and CompositionCrystal Structure of Mox-1, a Unique Plasmid-Mediated Class C -Lactamase with Hydrolytic Activity towards MoxalactamKinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the β-Lactamase from Mycobacterium tuberculosisExploring the role of a conserved class A residue in the Ω-Loop of KPC-2 β-lactamase: a mechanism for ceftazidime hydrolysisClass D β-lactamases: a reappraisal after five decades
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Robert A Bonomo
@ast
Robert A Bonomo
@en
Robert A Bonomo
@es
Robert A Bonomo
@nl
type
label
Robert A Bonomo
@ast
Robert A Bonomo
@en
Robert A Bonomo
@es
Robert A Bonomo
@nl
prefLabel
Robert A Bonomo
@ast
Robert A Bonomo
@en
Robert A Bonomo
@es
Robert A Bonomo
@nl
P106
P21
P31
P496
0000-0002-3299-894X