Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis

Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis

Item
http://www.wikidata.org/entity/Q27679180
Tracing binding modes in hit-to-lead optimization: chameleon-like poses of aspartic protease inhibitorsStructure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complexAn Open and Shut Case: The Interaction of Magnesium with MST EnzymesSynthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site.Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategyStereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis.Lysine221 is the general base residue of the isochorismate synthase from Pseudomonas aeruginosa (PchA) in a reaction that is diffusion limited.Small-molecule inhibitor of the Shigella flexneri master virulence regulator VirF.A new salicylate synthase AmS is identified for siderophores biosynthesis in Amycolatopsis methanolica 239(T).When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode?When Inhibitors Do Not Inhibit: Critical Evaluation of Rational Drug Design Targeting Chorismate Mutase fromMycobacterium tuberculosis
P2860

Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis

Item
http://www.wikidata.org/entity/Q27679180
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@ast
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@en
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@nl
type
label
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@ast
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@en
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@nl
prefLabel
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@ast
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@en
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@nl
P1433
P1476
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P921
P3181
P356
P1433
P1476
Implications of binding mode a ...... rom Mycobacterium tuberculosis
@en
P2093
P304
P31
P3181
P356
P407
P433
P478
P50
P577
P698
P921