about
Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formationThe structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosisImplications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosisThe substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibitionThe BC component of ABC toxins is an RHS-repeat-containing protein encapsulation deviceStructure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generationRepurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosisAlternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosisA covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocketStructures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active SiteStructure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complexCrystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxinThe crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphateThe structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthaseThe structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymesA highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosisCholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallographyThe Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulationSynthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site.The TB structural genomics consortium: providing a structural foundation for drug discovery.The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activityIdentification of extracellular siderophores and a related peptide from the endophytic fungus Epichloë festucae in culture and endophyte-infected Lolium perenne.Crystallization of a protein using dehydration without a precipitant.High throughput crystallography of TB drug targets.Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.Combining cross-crystal averaging and MRSAD to phase a 4354-amino-acid structure.Prediction of the substrate for nonribosomal peptide synthetase (NRPS) adenylation domains by virtual screening.Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis.Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) from Mycobacterium tuberculosis.The cloning, expression and crystallisation of a thermostable arginase.Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis.Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas.Making the most of two crystals: structural analysis of a conserved hypothetical protein using native gel screening and SAD phasing.Using structural genomics to understand Mycobacterium tuberculosis.Expression and purification of high sulfur and high glycine-tyrosine keratin-associated proteins (KAPs) for biochemical and biophysical characterization.
P50
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P50
description
forsker
@nb
onderzoeker uit Nieuw-Zeeland
@nl
researcher, ORCID id # 0000-0003-3660-452X
@en
name
J. Shaun Lott
@ast
J. Shaun Lott
@nl
Shaun Lott
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Shaun Lott
@es
Shaun Lott
@nb
type
label
J. Shaun Lott
@ast
J. Shaun Lott
@nl
Shaun Lott
@en
Shaun Lott
@es
Shaun Lott
@nb
altLabel
J. Shaun Lott
@en
prefLabel
J. Shaun Lott
@ast
J. Shaun Lott
@nl
Shaun Lott
@en
Shaun Lott
@es
Shaun Lott
@nb
P106
P1153
7102972485
P27
P31
P496
0000-0003-3660-452X