Structural Characterization and Computer-Aided Optimization of a Small-Molecule Inhibitor of the Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton

Structural Characterization and Computer-Aided Optimization of a Small-Molecule Inhibitor of the Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton

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http://www.wikidata.org/entity/Q27679277
Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells.Structure-based virtual screening for drug discovery: principles, applications and recent advances.1,2-Azaborine: The Boron-Nitrogen Derivative of ortho-BenzyneSmall molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change.New insights into the regulation and cellular functions of the ARP2/3 complex.Pharmacological inhibition of actin assembly to target tumor cell motility.The Arp2/3 Regulatory System and Its Deregulation in Cancer.Using physics-based pose predictions and free energy perturbation calculations to predict binding poses and relative binding affinities for FXR ligands in the D3R Grand Challenge 2.Morphodynamics of the Actin-Rich Cytoskeleton in Entamoeba histolytica.
P2860

Structural Characterization and Computer-Aided Optimization of a Small-Molecule Inhibitor of the Arp2/3 Complex, a Key Regulator of the Actin Cytoskeleton

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http://www.wikidata.org/entity/Q27679277
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2012 nî lūn-bûn
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2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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Structural characterization an ...... ator of the actin cytoskeleton
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P50
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P698
P921
P932