Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor - Wikidata - awgldk - TriplyDB

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

http://www.wikidata.org/entity/Q27679284

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Discoidin Domain Receptors: Potential Actors and Targets in Cancer Discoidin domain receptor 1 (DDR1) kinase as target for structure-based drug discovery A membrane-type-1 matrix metalloproteinase (MT1-MMP)-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells Structural Mechanisms Determining Inhibition of the Collagen Receptor DDR1 by Selective and Multi-Targeted Type II Kinase Inhibitors KRAS-driven lung adenocarcinoma: combined DDR1/Notch inhibition as an effective therapy Systematic Quality Control Analysis of LINCS Data Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts.Discoidin domain receptors in disease.Discoidin domain receptor functions in physiological and pathological conditions.Novel cross talk between IGF-IR and DDR1 regulates IGF-IR trafficking, signaling and biological responses.Protective effects of genetic inhibition of Discoidin Domain Receptor 1 in experimental renal disease Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).Discoidin domain receptors: a proteomic portrait.Discoidin domain receptor 2 signaling networks and therapy in lung cancer.DDR1 enhances invasion and metastasis of gastric cancer via epithelial-mesenchymal transition.Ultra-deep tyrosine phosphoproteomics enabled by a phosphotyrosine superbinder.Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors.Discovery of a broad spectrum antiproliferative agent with selectivity for DDR1 kinase: cell line-based assay, kinase panel, molecular docking, and toxicity studies.Collagen signaling enhances tumor progression after anti-VEGF therapy in a murine model of pancreatic ductal adenocarcinoma.Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1.The study of homology between tumor progression genes and members of retroviridae as a tool to predict target-directed therapy failure.Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells.Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.In vitro assessment of antitumor activities of the PI3K/mTOR inhibitor GSK2126458.Discovery of a Nanomolar Multikinase Inhibitor (KST016366): A New Benzothiazole Derivative with Remarkable Broad-Spectrum Antiproliferative Activity.Tetrahydroisoquinoline-7-carboxamide Derivatives as New Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors.Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.Identification of novel inhibitors of DDR1 against idiopathic pulmonary fibrosis by integrative transcriptome meta-analysis, computational and experimental screening.

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Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

http://www.wikidata.org/entity/Q27679284

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@ast

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@en

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@nl

type

label

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@ast

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@en

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@nl

prefLabel

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@ast

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@en

Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor

@nl

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ACS Chemical Biology

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Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor

@en

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Alex N Bullock

http://www.w3.org/2001/XMLSchema#string

Anna Mandinova

http://www.w3.org/2001/XMLSchema#string

Ellen L Weisberg

http://www.w3.org/2001/XMLSchema#string

Feiyang Liu

http://www.w3.org/2001/XMLSchema#string

Hong Wu

http://www.w3.org/2001/XMLSchema#string

Hwan Geun Choi

http://www.w3.org/2001/XMLSchema#string

Hyung-Gu Kim

http://www.w3.org/2001/XMLSchema#string

James D Griffin

http://www.w3.org/2001/XMLSchema#string

Jinhua Wang

http://www.w3.org/2001/XMLSchema#string

Li Tan

http://www.w3.org/2001/XMLSchema#string

P2860

Cell signaling by receptor tyrosine kinases

Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma

Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors

Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors

Comprehensive analysis of kinase inhibitor selectivity

Overexpression of discoidin domain receptor 1 increases the migration and invasion of hepatocellular carcinoma cells in association with matrix metalloproteinase.

Quantitative chemical proteomics reveals mechanisms of action of clinical ABL kinase inhibitors.

p53 induction and activation of DDR1 kinase counteract p53-mediated apoptosis and influence p53 regulation through a positive feedback loop.

DDR1 receptor tyrosine kinase promotes prosurvival pathway through Notch1 activation.

Discoidin domain receptor tyrosine kinases: new players in cancer progression

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2145-2150

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scholarly article

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3651416

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10.1021/CB400430T

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10

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8

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2013-08-13T00:00:00Z

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253647775

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23899692

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3800496

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