Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site
about
Alzheimer's disease--a panorama glimpseStructural Mechanism of the Interaction of Alzheimer Disease Aβ Fibrils with the Non-steroidal Anti-inflammatory Drug (NSAID) Sulindac SulfideStructural heterogeneity in transmembrane amyloid precursor protein homodimer is a consequence of environmental selection.Extension of a protein docking algorithm to membranes and applications to amyloid precursor protein dimerization.Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer's disease and transgenic mouse models.Evolutionary-guided de novo structure prediction of self-associated transmembrane helical proteins with near-atomic accuracy.Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratioImpact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein.How amyloid precursor protein protects itself from cleavage.The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices.Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.The Role of microRNAs in Alzheimer's Disease and Their Therapeutic Potentials.Binding of Bexarotene to the Amyloid Precursor Protein Transmembrane Domain in Liposomes Alters its α-Helical Conformation but Inhibits γ-Secretase Non-Selectively.Mechanism of Allosteric Coupling into and through the Plasma Membrane by EGFR.Coupled Transmembrane Substrate Docking and Helical Unwinding in Intramembrane Proteolysis of Amyloid Precursor Protein
P2860
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P2860
Familial Alzheimer’s mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site
description
2014 nî lūn-bûn
@nan
2014 թուականին հրատարակուած գիտական յօդուած
@hyw
2014 թվականին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@ast
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@en
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@nl
type
label
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@ast
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@en
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@nl
prefLabel
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@ast
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@en
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@nl
P2093
P2860
P3181
P356
P1476
Familial Alzheimer’s mutations ...... cessibility of ε-cleavage site
@en
P2093
Chunyu Wang
David J Rosenman
Eric Gamache
Maria M Lopez
Yue-Ming Li
P2860
P2888
P3181
P356
10.1038/NCOMMS4037
P407
P577
2014-01-01T00:00:00Z
P6179
1007507073