The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.
about
γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains.Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease.Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.How γ-secretase hits a moving target.Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ.Defining the minimum substrate and charge recognition model of gamma-secretase.Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices.Amyloid β42 peptide is toxic to non-neural cells in Drosophila yielding a characteristic metabolite profile and the effect can be suppressed by PI3K.Both positional and chemical variables control in vitro proteolytic cleavage of a presenilin ortholog.Oxidant/Antioxidant Imbalance in Alzheimer's Disease: Therapeutic and Diagnostic Prospects.Is Beta-Amyloid Accumulation a Cause or Consequence of Alzheimer's Disease?Effect of Cholesterol on Membrane Fluidity and Association of Aβ Oligomers and Subsequent Neuronal Damage: A Double-Edged Sword
P2860
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P2860
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.
@en
type
label
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.
@en
prefLabel
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.
@en
P2093
P2860
P356
P1433
P1476
The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
@en
P2093
Daniel R Montagna
Dennis J Selkoe
Michael S Wolfe
P2860
P356
10.7554/ELIFE.17578
P407
P577
2016-08-31T00:00:00Z