Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityMechanisms and regulation of mitotic recombination in Saccharomyces cerevisiaeTelomere shortening in human diseasesThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesR-loops in proliferating cells but not in the brain: implications for AOA2 and other autosomal recessive ataxiasMre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repairAtaxia.DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.Chl1 DNA helicase regulates Scc2 deposition specifically during DNA-replication in Saccharomyces cerevisiae.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairRare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening studySae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallographyEnd resection at double-strand breaks: mechanism and regulation.The non-catalytic "cap domain" of a mycobacterial metallophosphoesterase regulates its expression and localization in the cell.Autoinhibition of bacteriophage T4 Mre11 by its C-terminal domain.Synthetic viability genomic screening defines Sae2 function in DNA repair.Recognition and repair of chemically heterogeneous structures at DNA endsTetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.Identification of the interactors of human nibrin (NBN) and of its 26 kDa and 70 kDa fragments arising from the NBN 657del5 founder mutation.In silico characterization and Molecular modeling of double-strand break repair protein MRE11 from Phoenix dactylifera v deglet nour.Disruption of the bacteriophage T4 Mre11 dimer interface reveals a two-state mechanism for exonuclease activityS. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.Cohesin codes - interpreting chromatin architecture and the many facets of cohesin function.ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complexDNA Replication Stress Phosphoproteome Profiles Reveal Novel Functional Phosphorylation Sites on Xrs2 in Saccharomyces cerevisiaeMechanism and regulation of DNA end resection in eukaryotesA mutation in the FHA domain of Coprinus cinereus Nbs1 Leads to Spo11-independent meiotic recombination and chromosome segregationDisease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms.NBN Gene Polymorphisms and Cancer Susceptibility: A Systemic Review.The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.Repair of double-strand breaks by end joining.DNA damage sensing by the ATM and ATR kinases.Next-generation sequencing for inherited breast cancer risk: counseling through the complexity.Structural studies of DNA end detection and resection in homologous recombination.ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.Metallophosphoesterases: structural fidelity with functional promiscuity.CtIP/Ctp1/Sae2, molecular form fit for function.
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Structure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signaling
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@ast
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@en
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@nl
type
label
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@ast
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@en
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@nl
prefLabel
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@ast
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@en
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@nl
P2093
P2860
P50
P3181
P356
P1476
Structure of Mre11–Nbs1 comple ...... tions and DNA damage signaling
@en
P2093
Britta Coordes
Carolin Möckel
Christian B Schiller
Florian Schlauderer
Heidi Feldmann
Ilaria Guerini
P2860
P2888
P304
P3181
P356
10.1038/NSMB.2323
P50
P577
2012-06-17T00:00:00Z
P5875
P6179
1005342409