Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.
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Synthetic viability genomic screening defines Sae2 function in DNA repair.Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 ActivityReplication fork stability confers chemoresistance in BRCA-deficient cellsDNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous RecombinationS. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex.Overhang polarity of chromosomal double-strand breaks impacts kinetics and fidelity of yeast non-homologous end joiningDNA Replication Stress Phosphoproteome Profiles Reveal Novel Functional Phosphorylation Sites on Xrs2 in Saccharomyces cerevisiaeMechanism and regulation of DNA end resection in eukaryotesKinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitorsCoupling end resection with the checkpoint response at DNA double-strand breaks.Slx4 scaffolding in homologous recombination and checkpoint control: lessons from yeast.Genetic and biochemical evidences reveal novel insights into the mechanism underlying Saccharomyces cerevisiae Sae2-mediated abrogation of DNA replication stress.Xrs2 Dependent and Independent Functions of the Mre11-Rad50 ComplexWhen two is not enough: a CtIP tetramer is required for DNA repair by Homologous Recombination.Genetic separation of Sae2 nuclease activity from Mre11 nuclease functions in budding yeast.Enhancement of BLM-DNA2-Mediated Long-Range DNA End Resection by CtIP.Sgs1 Binding to Rad51 Stimulates Homology-Directed DNA Repair in Saccharomyces cerevisiae.EZH2 promotes degradation of stalled replication forks by recruiting MUS81 through histone H3 trimethylation.Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance.The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.Regulatory control of DNA end resection by Sae2 phosphorylationProcessing of DNA Ends in the Maintenance of Genome Stability
P2860
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P2860
Sae2 promotes DNA damage resistance by removing the Mre11-Rad50-Xrs2 complex from DNA and attenuating Rad53 signaling.
description
2015 nî lūn-bûn
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2015 թուականի Մարտին հրատարակուած գիտական յօդուած
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2015 թվականի մարտին հրատարակված գիտական հոդված
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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name
Sae2 promotes DNA damage resis ...... d attenuating Rad53 signaling.
@ast
Sae2 promotes DNA damage resis ...... d attenuating Rad53 signaling.
@en
type
label
Sae2 promotes DNA damage resis ...... d attenuating Rad53 signaling.
@ast
Sae2 promotes DNA damage resis ...... d attenuating Rad53 signaling.
@en
prefLabel
Sae2 promotes DNA damage resis ...... d attenuating Rad53 signaling.
@ast
Sae2 promotes DNA damage resis ...... d attenuating Rad53 signaling.
@en
P2093
P2860
P3181
P356
P1476
Sae2 promotes DNA damage resis ...... d attenuating Rad53 signaling.
@en
P2093
Leonid A Timashev
Lorraine S Symington
Roberto A Donnianni
Sarah K Deng
Stephen C Kowalczykowski
P2860
P304
P3181
P356
10.1073/PNAS.1503331112
P407
P577
2015-03-23T00:00:00Z