Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA) - Wikidata - awgldk - TriplyDB

Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)

Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)

http://www.wikidata.org/entity/Q27681427

about

Reviving Lonidamine and 6-Diazo-5-oxo-L-norleucine to Be Used in Combination for Metabolic Cancer Therapy Determination of phosphate-activated glutaminase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry)Metabolic plasticity in resting and thrombin activated platelets Vemurafenib resistance reprograms melanoma cells towards glutamine dependence.Glutaminolysis Was Induced by TGF-β1 through PP2Ac Regulated Raf-MEK-ERK Signaling in Endothelial Cells.Targeting glutamine metabolism rescues mice from late-stage cerebral malaria.Nuclear Gln3 Import Is Regulated by Nitrogen Catabolite Repression Whereas Export Is Specifically Regulated by Glutamine Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular Parasite Toxoplasma gondii Alphavirus Encephalomyelitis: Mechanisms and Approaches to Prevention of Neuronal Damage.Protective Effects of Glutamine Antagonist 6-Diazo-5-Oxo-l-Norleucine in Mice with Alphavirus Encephalomyelitis Structural basis for exploring the allosteric inhibition of human kidney type glutaminase.Tumor-associated mutant p53 promotes cancer cell survival upon glutamine deprivation through p21 induction.Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach.A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition.Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation.Glutamine antagonist-mediated immune suppression decreases pathology but delays virus clearance in mice during nonfatal alphavirus encephalomyelitis.Bioanalysis of 6-diazo-5-oxo-l-norleucine in plasma and brain by ultra-performance liquid chromatography mass spectrometry.Oncogenic regulation of tumor metabolic reprogramming.A natural inhibitor of kidney-type glutaminase: a withanolide from Physalis pubescens with potent anti-tumor activity.Structure of 6-diazo-5-oxo-norleucine-bound human gamma-glutamyl transpeptidase 1, a novel mechanism of inactivation.Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.Inhibition of Glycolysis and Glutaminolysis: Emerging Drug Discovery Approach to Combat Cancer.We're Not "DON" Yet: Optimal Dosing and Prodrug Delivery of

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Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)

http://www.wikidata.org/entity/Q27681427

description

2014 nî lūn-bûn

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2014 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հունվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Structural Basis for the Activ ...... Kidney-Type Glutaminase (KGA)

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Structural Basis for the Activ ...... Kidney-Type Glutaminase (KGA)

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Structural Basis for the Activ ...... Kidney-Type Glutaminase (KGA)

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Structural Basis for the Activ ...... Kidney-Type Glutaminase (KGA)

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Structural Basis for the Activ ...... Kidney-Type Glutaminase (KGA)

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Structural Basis for the Activ ...... Kidney-Type Glutaminase (KGA)

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Scientific Reports

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Structural Basis for the Activ ...... Kidney-Type Glutaminase (KGA)

@en

P2093

J Sivaraman

http://www.w3.org/2001/XMLSchema#string

K Thangavelu

http://www.w3.org/2001/XMLSchema#string

Qing Yun Chong

http://www.w3.org/2001/XMLSchema#string

P2860

Full-length human glutaminase in complex with an allosteric inhibitor

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S

PHENIX: a comprehensive Python-based system for macromolecular structure solution

PROCHECK: a program to check the stereochemical quality of protein structures

Processing of X-ray diffraction data collected in oscillation mode

Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu

The crystal structure of phosphinothricin in the active site of glutamine synthetase illuminates the mechanism of enzymatic inhibition

Functional and Structural Characterization of Four Glutaminases from Escherichia coli and Bacillus subtilis †

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3827

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scholarly article

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3596391

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10.1038/SREP03827

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4

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2014-01-23T00:00:00Z

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24451979

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4929687

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