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Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP-2The BNIP-2 and Cdc42GAP homology/Sec14p-like domain of BNIP-Salpha is a novel apoptosis-inducing sequenceBrain-specific BNIP-2-homology protein Caytaxin relocalises glutaminase to neurite terminals and reduces glutamate levelsActive Mek2 as a regulatory scaffold that promotes Pin1 binding to BPGAP1 to suppress BPGAP1-induced acute Erk activation and cell migrationNerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neuronsThe SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migrationSprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling.BPGAP1 interacts with cortactin and facilitates its translocation to cell periphery for enhanced cell migrationModularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signalingK-ras/PI3K-Akt signaling is essential for zebrafish hematopoiesis and angiogenesisNuSAP governs chromosome oscillation by facilitating the Kid-generated polar ejection forceStructural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolismStructural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)Concerted regulation of cell dynamics by BNIP-2 and Cdc42GAP homology/Sec14p-like, proline-rich, and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signalingTyrosine phosphorylation of the Bcl-2-associated protein BNIP-2 by fibroblast growth factor receptor-1 prevents its binding to Cdc42GAP and Cdc42Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domainSuc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2Epidermal growth factor activates the Rho GTPase-activating protein (GAP) Deleted in Liver Cancer 1 via focal adhesion kinase and protein phosphatase 2ASimulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilinAngiotensin II stimulates system y+ and cationic amino acid transporter gene expression in cultured vascular smooth muscle cellsJuxtanodin: an oligodendroglial protein that promotes cellular arborization and 2',3'-cyclic nucleotide-3'-phosphodiesterase traffickingInterleukin-1 beta and tumor necrosis factor-alpha stimulate the cat-2 gene of the L-arginine transporter in cultured vascular smooth muscle cellsProtein encoded by the Axin(Fu) allele effectively down-regulates Wnt signaling but exerts a dominant negative effect on c-Jun N-terminal kinase signalingCortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control.SmgGDS antagonizes BPGAP1-induced Ras/ERK activation and neuritogenesis in PC12 cell differentiation.KIF5B transports BNIP-2 to regulate p38 mitogen-activated protein kinase activation and myoblast differentiation.Molecular mechanistic insights into the endothelial receptor mediated cytoadherence of Plasmodium falciparum-infected erythrocytes.The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain.Cross-species analyses identify the BNIP-2 and Cdc42GAP homology (BCH) domain as a distinct functional subclass of the CRAL_TRIO/Sec14 superfamilyBNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain.A genetic pathway composed of Sox14 and Mical governs severing of dendrites during pruningStructural Basis for a Unique ATP Synthase Core Complex from Nanoarcheaum equitans.Topography induces differential sensitivity on cancer cell proliferation via Rho-ROCK-Myosin contractility.A Cdo-Bnip-2-Cdc42 signaling pathway regulates p38alpha/beta MAPK activity and myogenic differentiationStructural basis for exploring the allosteric inhibition of human kidney type glutaminase.In-silico approaches to multi-target drug discovery : computer aided multi-target drug design, multi-target virtual screening.Functional plasticity of the BNIP-2 and Cdc42GAP Homology (BCH) domain in cell signaling and cell dynamics.YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth.Using zebrafish for studying Rho GTPases signaling in vivo.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Boon Chuan Low
@ast
Boon Chuan Low
@en
Boon Chuan Low
@es
Boon Chuan Low
@nl
Boon Chuan Low
@sl
type
label
Boon Chuan Low
@ast
Boon Chuan Low
@en
Boon Chuan Low
@es
Boon Chuan Low
@nl
Boon Chuan Low
@sl
prefLabel
Boon Chuan Low
@ast
Boon Chuan Low
@en
Boon Chuan Low
@es
Boon Chuan Low
@nl
Boon Chuan Low
@sl
P106
P2456
P31
P496
0000-0003-0756-096X