Structural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis Mechanism
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Paralog Specific Hsp90 Inhibitors - A Brief History and a Bright FutureReview: The HSP90 molecular chaperone-an enigmatic ATPaseMolecular chaperones: guardians of the proteome in normal and disease statesTargeting Hsp90 in urothelial carcinomaSurvivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasionAtomic structure of Hsp90-Cdc37-Cdk4 reveals that Hsp90 traps and stabilizes an unfolded kinaseMechanistic Asymmetry in Hsp90 DimersThe Hsp70/Hsp90 Chaperone Machinery in Neurodegenerative DiseasesDeletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.Crystallization and preliminary X-ray diffraction analysis of Trap1 complexed with Hsp90 inhibitorsThe Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.Hurt, tired and queasy: Specific variants in the ATPase domain of the TRAP1 mitochondrial chaperone are associated with common, chronic "functional" symptomatology including pain, fatigue and gastrointestinal dysmotility.The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.Mitochondrial Hsp90 is a ligand-activated molecular chaperone coupling ATP binding to dimer closure through a coiled-coil intermediate.Crowding Activates Heat Shock Protein 90.Elucidating the mechanism of substrate recognition by the bacterial Hsp90 molecular chaperone.TRAP1: a viable therapeutic target for future cancer treatments?NMR characterization of HtpG, the E. coli Hsp90, using sparse labeling with 13C-methyl alanine.Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells.Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.Symmetry broken and rebroken during the ATP hydrolysis cycle of the mitochondrial Hsp90 TRAP1.How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches.Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.2.4 Å resolution crystal structure of human TRAP1NM, the Hsp90 paralog in the mitochondrial matrix.Cooperation of local motions in the Hsp90 molecular chaperone ATPase mechanism.A novel N-terminal extension in mitochondrial TRAP1 serves as a thermal regulator of chaperone activity.Hsp90 Sensitivity to ADP Reveals Hidden Regulation Mechanisms.A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.The HSP90 chaperone machinery.Molecular mechanism of bacterial Hsp90 pH-dependent ATPase activity.Four-colour FRET reveals directionality in the Hsp90 multicomponent machinery.Redox Aspects of Chaperones in Cardiac Function.The HSP90 Family: Structure, Regulation, Function, and Implications in Health and Disease
P2860
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P2860
Structural Asymmetry in the Closed State of Mitochondrial Hsp90 (TRAP1) Supports a Two-Step ATP Hydrolysis Mechanism
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@ast
Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@en
Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@nl
type
label
Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@ast
Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@en
Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@nl
prefLabel
Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@ast
Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@en
Structural Asymmetry in the Cl ...... -Step ATP Hydrolysis Mechanism
@nl
P2093
P2860
P3181
P1433
P1476
Structural asymmetry in the cl ...... -step ATP hydrolysis mechanism
@en
P2093
David A Agard
James R Partridge
Michael A Kennedy
Theresa A Ramelot
P2860
P304
P3181
P356
10.1016/J.MOLCEL.2013.12.023
P577
2014-01-01T00:00:00Z