Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.

Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.

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http://www.wikidata.org/entity/Q39768761
In silico studies in drug research against neurodegenerative diseases.Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.Increase of enzyme activity through specific covalent modification with fragments.Atomistic simulations and network-based modeling of the Hsp90-Cdc37 chaperone binding with Cdk4 client protein: A mechanism of chaperoning kinase clients by exploiting weak spots of intrinsically dynamic kinase domains.Reliability assessment for large-scale molecular dynamics approximations.Discovery of new molecular entities able to strongly interfere with Hsp90 C-terminal domain.Protein stability and dynamics influenced by ligands in extremophilic complexes - a molecular dynamics investigation.The diverse roles of Hsp90 and where to find them.A switch point in the molecular chaperone Hsp90 responding to client interaction.Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection.Investigating molecular interactions between oxidized neuroglobin and cytochrome c.Protein design: from computer models to artificial intelligenceSynthesis of Functionalized 2-(4-Hydroxyphenyl)-3-methylbenzofuran Allosteric Modulators of Hsp90 Activity
P2860

Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands.

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http://www.wikidata.org/entity/Q39768761
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年学术文章
@wuu
2016年学术文章
@zh-cn
2016年学术文章
@zh-hans
2016年学术文章
@zh-my
2016年学术文章
@zh-sg
2016年學術文章
@yue
2016年學術文章
@zh
2016年學術文章
@zh-hant
name
Molecular Dynamics Simulations ...... of Hsp90 by Designed Ligands.
@en
Molecular Dynamics Simulations ...... of Hsp90 by Designed Ligands.
@nl
type
label
Molecular Dynamics Simulations ...... of Hsp90 by Designed Ligands.
@en
Molecular Dynamics Simulations ...... of Hsp90 by Designed Ligands.
@nl
prefLabel
Molecular Dynamics Simulations ...... of Hsp90 by Designed Ligands.
@en
Molecular Dynamics Simulations ...... of Hsp90 by Designed Ligands.
@nl
P1433
P1476
P2093
P2860
P2888
P304
P31
P356
P407
P478
P50
P577
P6179
P698
P921
P932
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P1433
P1476
Molecular Dynamics Simulations ...... of Hsp90 by Designed Ligands.
@en
P2093
P2860
P2888
P304
P31
P356
P407
P478
P50
P577
P6179
P698
P921
P932