ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
about
ATM-Dependent Phosphorylation of All Three Members of the MRN Complex: From Sensor to AdaptorThe Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changesRecruitment and activation of the ATM kinase in the absence of DNA-damage sensors.Emerging critical roles of Fe-S clusters in DNA replication and repair.DNA end recognition by the Mre11 nuclease dimer: insights into resection and repair of damaged DNA.Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairTel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand BreaksDesigning and defining dynamic protein cage nanoassemblies in solution.RNF8 E3 Ubiquitin Ligase Stimulates Ubc13 E2 Conjugating Activity That Is Essential for DNA Double Strand Break Signaling and BRCA1 Tumor Suppressor RecruitmentRecognition and repair of chemically heterogeneous structures at DNA endsTetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response.Interdependence of the rad50 hook and globular domain functionsEXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil DomainDNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous RecombinationATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complexSharpening the ends for repair: mechanisms and regulation of DNA resection.Dynamic structures in DNA damage responses & cancer.The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.Archaeal genome guardians give insights into eukaryotic DNA replication and damage response proteins.The cutting edges in DNA repair, licensing, and fidelity: DNA and RNA repair nucleases sculpt DNA to measure twice, cut once.Structural studies of DNA end detection and resection in homologous recombination.ATP puts the brake on DNA double-strand break repair: a new study shows that ATP switches the Mre11-Rad50-Nbs1 repair factor between signaling and processing of DNA ends.CtIP/Ctp1/Sae2, molecular form fit for function.Invited review: Architectures and mechanisms of ATP binding cassette proteins.Coupling end resection with the checkpoint response at DNA double-strand breaks.How do telomeres and NHEJ coexist?Eukaryotic Rad50 functions as a rod-shaped dimer.Releasing the cohesin ring: A rigid scaffold model for opening the DNA exit gate by Pds5 and Wapl.Functions and regulation of the MRX complex at DNA double-strand breaks.Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.A network of allosterically coupled residues in the bacteriophage T4 Mre11-Rad50 complexWhat Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites.MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA.Post-translational methylations of the archaeal Mre11:Rad50 complex throughout the DNA damage response.Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.Targeting Cellular Metabolism Chemosensitizes the Doxorubicin-Resistant Human Breast Adenocarcinoma Cells.Identification of ATIC as a Novel Target for Chemoradiosensitization.
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P2860
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
description
2014 nî lūn-bûn
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2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@ast
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@en
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@nl
type
label
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@ast
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@en
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@nl
prefLabel
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@ast
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@en
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@nl
P2093
P2860
P50
P356
P1433
P1476
ATP-driven Rad50 conformations ...... , and ATM checkpoint signaling
@en
P2093
Gareth J Williams
Grant Guenther
Jeff Kuhnlein
Ji-Hoon Lee
Paul Russell
Rajashree A Deshpande
Scott Classen
Tanya T Paull
P2860
P304
P356
10.1002/EMBJ.201386100
P407
P577
2014-03-03T00:00:00Z