Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
about
Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.Replication stress and cancer: it takes two to tango.Inhibition of Nucleotide Synthesis Targets Brain Tumor Stem Cells in a Subset of GlioblastomaProteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets.ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.Effective double whammy targets DNA synthesis in leukemia.Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.
P2860
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P2860
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@ast
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@en
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@nl
type
label
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@ast
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@en
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@nl
prefLabel
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@ast
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@en
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@nl
P2093
P2860
P356
P1476
Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication
@en
P2093
Amanda L Armijo
Ari Gordin
Arnon Lavie
Colette Martin
David A Nathanson
Dean O Campbell
Elizabeth Dimitrova
Harvey R Herschman
Hsiang-I Liao
Jason T Lee
P2860
P304
P356
10.1084/JEM.20131738
P407
P577
2014-03-10T00:00:00Z