X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

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http://www.wikidata.org/entity/Q27681891
From SARS to MERS: crystallographic studies on coronaviral proteases enable antiviral drug designStructural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitinThe SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds.A chimeric virus-mouse model system for evaluating the function and inhibition of papain-like proteases of emerging coronavirusesMurine coronavirus ubiquitin-like domain is important for papain-like protease stability and viral pathogenesis.Catalytic function and substrate specificity of the papain-like protease domain of nsp3 from the Middle East respiratory syndrome coronavirus.SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzymeLigand-induced Dimerization of Middle East Respiratory Syndrome (MERS) Coronavirus nsp5 Protease (3CLpro): IMPLICATIONS FOR nsp5 REGULATION AND THE DEVELOPMENT OF ANTIVIRALS.X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions.Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoVX-ray Structure and Enzymatic Activity Profile of a Core Papain-like Protease of MERS Coronavirus with utility for structure-based drug design.DUBs, the regulation of cell identity and disease.Computational modeling of the bat HKU4 coronavirus 3CL(pro) inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus.Recent progress in the discovery of inhibitors targeting coronavirus proteases.RNA-virus proteases counteracting host innate immunity.Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species.The papain-like protease determines a virulence trait that varies among members of the SARS-coronavirus species
P2860

X-ray Structural and Biological Evaluation of a Series of Potent and Highly Selective Inhibitors of Human Coronavirus Papain-like Proteases

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http://www.wikidata.org/entity/Q27681891
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2014 nî lūn-bûn
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2014 թուականի Մարտին հրատարակուած գիտական յօդուած
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2014 թվականի մարտին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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X-ray Structural and Biologica ...... onavirus Papain-like Proteases
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P2860
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P433
P478
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P5875
P698
P921
P932