Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide - Wikidata - awgldk - TriplyDB

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide

Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide

http://www.wikidata.org/entity/Q27682411

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Ribosomal Antibiotics: Contemporary Challenges The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis Macrolide antibiotics allosterically predispose the ribosome for translation arrest.Using the Tools and Resources of the RCSB Protein Data Bank.Ribosome rearrangements at the onset of translational bypassing Relaxed selection drives a noisy noncoding transcriptome in members of the Mycobacterium tuberculosis complex.Sequence selectivity of macrolide-induced translational attenuation The general mode of translation inhibition by macrolide antibiotics Macrolide-peptide conjugates as probes of the path of travel of the nascent peptides through the ribosome.Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolution.Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin A Nascent Peptide Signal Responsive to Endogenous Levels of Polyamines Acts to Stimulate Regulatory Frameshifting on Antizyme mRNA Exploiting translational stalling peptides in an effort to extend azithromycin interaction within the prokaryotic ribosome nascent peptide exit tunnel.Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.Mechanisms of ribosome stalling by SecM at multiple elongation steps.Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center.Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size.The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.The conserved GTPase HflX is a ribosome splitting factor that binds to the E-site of the bacterial ribosome.Dual effect of chloramphenicol peptides on ribosome inhibition.Resistance to Macrolide Antibiotics in Public Health Pathogens.The macrolide antibiotic renaissance.Inducible Expression of both ermB and ermT Conferred High Macrolide Resistance in Streptococcus gallolyticus subsp. pasteurianus Isolates in China Drug sensing by the ribosome induces translational arrest via active site perturbation.Identification of Arabidopsis thaliana upstream open reading frames encoding peptide sequences that cause ribosomal arrest.A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.Nascent peptide assists the ribosome in recognizing chemically distinct small molecules.Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center.An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome.The use of high-throughput sequencing to investigate an outbreak of glycopeptide-resistant Enterococcus faecium with a novel quinupristin-dalfopristin resistance mechanism.Ribosome protection by antibiotic resistance ATP-binding cassette protein.Structural basis for antibiotic resistance mediated by the ABCF ATPase VmlR Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries

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Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide

http://www.wikidata.org/entity/Q27682411

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2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Nature Communications

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Molecular basis for erythromyc ...... on of the ErmBL leader peptide

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Alexander S Mankin

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Daniel N Wilson

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Haripriya Ramu

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Nora Vázquez-Laslop

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Pulkit Gupta

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Stefan Arenz

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P2860

Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

The structures of four macrolide antibiotics bound to the large ribosomal subunit

Mutations Outside the Anisomycin-Binding Site Can Make Ribosomes Drug-Resistant

Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating Ribosome

Structural insight into nascent polypeptide chain-mediated translational stalling.

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptide

Cryo-EM structure of the ribosome–SecYE complex in the membrane environment

Structural basis for TetM-mediated tetracycline resistance

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3501

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scholarly article

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232894

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10.1038/NCOMMS4501

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P478

5

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Otto Berninghausen

Roland Beckmann

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2014-03-24T00:00:00Z

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1042325415

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24662426

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4133097

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