Drug sensing by the ribosome induces translational arrest via active site perturbation.
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The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complexThe stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesisA comparison of the folding characteristics of free and ribosome-tethered polypeptide chains using limited proteolysis and mass spectrometryUsing the Tools and Resources of the RCSB Protein Data Bank.Ribosome rearrangements at the onset of translational bypassingCritical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain.The general mode of translation inhibition by macrolide antibioticsRibosomes slide on lysine-encoding homopolymeric A stretchesCryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolution.Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stallingThe mechanism of inhibition of protein synthesis by the proline-rich peptide oncocinMolecular dynamics simulations of large macromolecular complexes.Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.Mechanisms of ribosome stalling by SecM at multiple elongation steps.Integrated in vivo and in vitro nascent chain profiling reveals widespread translational pausing.Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.Quality over quantity: optimizing co-translational protein folding with non-'optimal' synonymous codons.Binding of Macrolide Antibiotics Leads to Ribosomal Selection against Specific Substrates Based on Their Charge and Size.The Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.The conserved GTPase HflX is a ribosome splitting factor that binds to the E-site of the bacterial ribosome.Dual effect of chloramphenicol peptides on ribosome inhibition.Resistance to Macrolide Antibiotics in Public Health Pathogens.The macrolide antibiotic renaissance.Structure of a human translation termination complex.Identification of Arabidopsis thaliana upstream open reading frames encoding peptide sequences that cause ribosomal arrest.A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.Cryo-EM structure of the spinach chloroplast ribosome reveals the location of plastid-specific ribosomal proteins and extensions.Nascent peptide assists the ribosome in recognizing chemically distinct small molecules.Ribosome protection by antibiotic resistance ATP-binding cassette protein.Erythromycin leads to differential protein expression through differences in electrostatic and dispersion interactions with nascent proteins.Structural basis for antibiotic resistance mediated by the ABCF ATPase VmlR
P2860
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P2860
Drug sensing by the ribosome induces translational arrest via active site perturbation.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Drug sensing by the ribosome induces translational arrest via active site perturbation.
@en
type
label
Drug sensing by the ribosome induces translational arrest via active site perturbation.
@en
prefLabel
Drug sensing by the ribosome induces translational arrest via active site perturbation.
@en
P2093
P2860
P1433
P1476
Drug sensing by the ribosome induces translational arrest via active site perturbation.
@en
P2093
Nora Vázquez-Laslop
Otto Berninghausen
Roland Beckmann
Sezen Meydan
Stefan Arenz
P2860
P304
P356
10.1016/J.MOLCEL.2014.09.014
P577
2014-10-08T00:00:00Z