Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy
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In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata SchizontsA single mutation in the gatekeeper residue in TgMAPKL-1 restores the inhibitory effect of a bumped kinase inhibitor on the cell cycle.Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice.In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninumSelective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy.Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse modelDevelopment of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.Enzyme Activity Assays for Protein Kinases: Strategies to Identify Active Substrates.Drug target identification in protozoan parasites.Extended-spectrum antiprotozoal bumped kinase inhibitors: A review.Toxoplasma gondii and Neospora caninum induce different host cell responses at proteome-wide phosphorylation events; a step forward for uncovering the biological differences between these closely related parasites.Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis.Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites.Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities.The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.Kinobead and Single-Shot LC-MS Profiling Identifies Selective PKD Inhibitors.In vitro growth inhibition of Theileria equi by bumped kinase inhibitors.Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii.Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites.
P2860
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P2860
Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy
description
2014 nî lūn-bûn
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2014 թուականին հրատարակուած գիտական յօդուած
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2014 թվականին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年論文
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2014年论文
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name
Neospora caninum calcium-depen ...... target for neosporosis therapy
@ast
Neospora caninum calcium-depen ...... target for neosporosis therapy
@en
Neospora caninum calcium-depen ...... target for neosporosis therapy
@nl
type
label
Neospora caninum calcium-depen ...... target for neosporosis therapy
@ast
Neospora caninum calcium-depen ...... target for neosporosis therapy
@en
Neospora caninum calcium-depen ...... target for neosporosis therapy
@nl
prefLabel
Neospora caninum calcium-depen ...... target for neosporosis therapy
@ast
Neospora caninum calcium-depen ...... target for neosporosis therapy
@en
Neospora caninum calcium-depen ...... target for neosporosis therapy
@nl
P2093
P2860
P1433
P1476
Neospora caninum Calcium-Depen ...... Target for Neosporosis Therapy
@en
P2093
Andrew Hemphill
Dustin J Maly
Erkang Fan
Ethan A Merritt
Katelyn R Keyloun
Kayode K Ojo
Latha Kallur Siddaramaiah
Molly C Reid
Pablo Winzer
Rama Subba Rao Vidadala
P2860
P304
P356
10.1371/JOURNAL.PONE.0092929
P407
P577
2014-01-01T00:00:00Z