Structures of human acetylcholinesterase in complex with pharmacologically important ligands
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Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site FlexibilityCrystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesteraseA conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a bis-imidazolium oximeThe Nature of Activated Non-classical Hydrogen Bonds: A Case Study on Acetylcholinesterase-Ligand ComplexesStructures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interfaceKey Targets for Multi-Target Ligands Designed to Combat NeurodegenerationDesigning Second Generation Anti-Alzheimer Compounds as Inhibitors of Human Acetylcholinesterase: Computational Screening of Synthetic Molecules and Dietary PhytochemicalsAnalyses of the Binding between Water Soluble C60 Derivatives and Potential Drug Targets through a Molecular Docking ApproachIsoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease.Correlation of the dynamics of native human acetylcholinesterase and its inhibited huperzine A counterpart from sub-picoseconds to nanoseconds.Pressure-induced molten globule state of human acetylcholinesterase: structural and dynamical changes monitored by neutron scattering.Crystal structure of snake venom acetylcholinesterase in complex with inhibitory antibody fragment Fab410 bound at the peripheral site: evidence for open and closed states of a back door channel.3-Oxoisoxazole-2(3H)-carboxamides and isoxazol-3-yl carbamates: Resistance-breaking acetylcholinesterase inhibitors targeting the malaria mosquito, Anopheles gambiae.Multitarget Strategy to Address Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and Computational Studies of Coumarin-Based Derivatives.Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment.Novel Triazole-Quinoline Derivatives as Selective Dual Binding Site Acetylcholinesterase Inhibitors.Exploration of a Library of 3,4-(Methylenedioxy)aniline-Derived Semicarbazones as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase: Design, Synthesis, and Evaluation.Molecular Docking Study on Galantamine Derivatives as Cholinesterase Inhibitors.Identification of novel acetylcholinesterase inhibitors through e-pharmacophore-based virtual screening and molecular dynamics simulations.Inhibition of acetylcholinesterase by two genistein derivatives: kinetic analysis, molecular docking and molecular dynamics simulationPotential acetylcholinesterase inhibitors: molecular docking, molecular dynamics, and in silico prediction.Novel Tacrine-Scutellarin Hybrids as Multipotent Anti-Alzheimer's Agents: Design, Synthesis and Biological Evaluation.Caffeine inhibits acetylcholinesterase, but not butyrylcholinesteraseAChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease.Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6.Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs.Zephycandidine A, the First Naturally Occurring Imidazo[1,2-f]phenanthridine Alkaloid from Zephyranthes candida, Exhibits Significant Anti-tumor and Anti-acetylcholinesterase Activities.High-throughput immuno-profiling of mamba (Dendroaspis) venom toxin epitopes using high-density peptide microarrays.Decline in serum cholinesterase activities predicts 2-year major adverse cardiac events.Effects of chlorophenoxy herbicides and their main transformation products on DNA damage and acetylcholinesterase activity.Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination.Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists.Computational Studies on Acetylcholinesterases.The potential role of in silico approaches to identify novel bioactive molecules from natural resources.Prolyl oligopeptidase and its role in the organism: attention to the most promising and clinically relevant inhibitors.Chalcone-based carbamates for Alzheimer's disease treatment.New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning.Development of 3D-QSAR Model for Acetylcholinesterase Inhibitors Using a Combination of Fingerprint, Molecular Docking, and Structure-Based Pharmacophore Approaches.
P2860
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P2860
Structures of human acetylcholinesterase in complex with pharmacologically important ligands
description
2012 nî lūn-bûn
@nan
2012 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Structures of human acetylchol ...... acologically important ligands
@ast
Structures of human acetylchol ...... acologically important ligands
@en
Structures of human acetylchol ...... acologically important ligands
@nl
type
label
Structures of human acetylchol ...... acologically important ligands
@ast
Structures of human acetylchol ...... acologically important ligands
@en
Structures of human acetylchol ...... acologically important ligands
@nl
prefLabel
Structures of human acetylchol ...... acologically important ligands
@ast
Structures of human acetylchol ...... acologically important ligands
@en
Structures of human acetylchol ...... acologically important ligands
@nl
P2093
P3181
P356
P1476
Structures of human acetylchol ...... acologically important ligands
@en
P2093
Ebony N Gary
Fiana Burshteyn
James Love
Jonah Cheung
Jude J Height
Matthew C Franklin
Michael J Rudolph
Michael S Cassidy
P304
P3181
P356
10.1021/JM300871X
P407
P577
2012-11-26T00:00:00Z