Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility

Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility

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http://www.wikidata.org/entity/Q27684173
Structures of paraoxon-inhibited human acetylcholinesterase reveal perturbations of the acyl loop and the dimer interfaceIs It Reliable to Use Common Molecular Docking Methods for Comparing the Binding Affinities of Enantiomer Pairs for Their Protein Target?The discovery of new acetylcholinesterase inhibitors derived from pharmacophore modeling, virtual screening, docking simulation and bioassays.Zephycandidine A, the First Naturally Occurring Imidazo[1,2-f]phenanthridine Alkaloid from Zephyranthes candida, Exhibits Significant Anti-tumor and Anti-acetylcholinesterase Activities.Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination.Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence.Recent developments in structural studies on acetylcholinesterase.The impact of crystallization conditions on structure-based drug design: A case study on the methylene blue/acetylcholinesterase complexA computational view on the significance of E-ring in binding of (+)-arisugacin A to acetylcholinesterase.Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimer's Disease.Synthesis and biological evaluation of phloroglucinol derivatives possessing α-glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activity.Positive cooperative regulation of double binding sites for human acetylcholinesterase.Identification of new allosteric sites and modulators of AChE through computational and experimental tools.Identification of novel acetylcholinesterase inhibitors designed by pharmacophore-based virtual screening, molecular docking and bioassayCharacterization and Validation of Albiziasaponin-A, Iso-Orientin, and Salvadorin Using a Rat Model of Alzheimer's Disease
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Structures of Human Acetylcholinesterase Bound to Dihydrotanshinone I and Territrem B Show Peripheral Site Flexibility

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http://www.wikidata.org/entity/Q27684173
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2013 nî lūn-bûn
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2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2013 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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name
Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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Structures of Human Acetylchol ...... ow Peripheral Site Flexibility
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P2093
P2860
P304
P31
P3181
P356
P433
P478
P577
P698
P921
P932