Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands - Wikidata - awgldk - TriplyDB

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

http://www.wikidata.org/entity/Q27683660

about

The notch ligand JAGGED1 as a target for anti-tumor therapy Notch ligand delta-like1: X-ray crystal structure and binding affinity Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.Ubiquitous Importance of Protein Glycosylation.Structural biology. Structural basis for Notch1 engagement of Delta-like 4 Impaired O-linked N-acetylglucosaminylation in the endoplasmic reticulum by mutated epidermal growth factor (EGF) domain-specific O-linked N-acetylglucosamine transferase found in Adams-Oliver syndrome.Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia.Significance of glycosylation in Notch signaling.The multiple roles of epidermal growth factor repeat O-glycans in animal development.Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch.Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.(1)H, (13)C and (15)N assignments of EGF domains 8-11 of human Notch-1.Lunatic fringe-mediated Notch signaling regulates adult hippocampal neural stem cell maintenance.A sweet development in Notch regulation.O-Glycosylation modulates the stability of epidermal growth factor-like repeats and thereby regulates Notch trafficking.Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.Inhibition of Delta-induced Notch signaling using fucose analogs.Variant in human POFUT1 reduces enzymatic activity and likely causes a recessive microcephaly, global developmental delay with cardiac and vascular features.Signal Transduction: Notch catches a Jagged edge.Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis.NOTCH activation promotes glycosyltransferase expression in human myeloid leukemia cells 1H, 13C and 15N assignments of EGF domains 4 to 7 of human Notch-1

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P2860

Fringe-mediated extension of O-linked fucose in the ligand-binding region of Notch1 increases binding to mammalian Notch ligands

http://www.wikidata.org/entity/Q27683660

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Fringe-mediated extension of O ...... ing to mammalian Notch ligands

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Fringe-mediated extension of O ...... ing to mammalian Notch ligands

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Fringe-mediated extension of O ...... ing to mammalian Notch ligands

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Fringe-mediated extension of O ...... ing to mammalian Notch ligands

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Proceedings of the National Academy of Sciences of the United States of America

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Fringe-mediated extension of O ...... ing to mammalian Notch ligands

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Chandramouli Chillakuri

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Devon Sheppard

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Hideyuki Takeuchi

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Paul Taylor

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Penny A Handford

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Robert S Haltiwanger

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P2860

A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

MolProbity: all-atom structure validation for macromolecular crystallography

Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways

A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition

Chemical synthesis, folding, and structural insights into O-fucosylated epidermal growth factor-like repeat 12 of mouse Notch-1 receptor

Notch signaling: cell fate control and signal integration in development

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Fringe is a glycosyltransferase that modifies Notch

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