Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Item
http://www.wikidata.org/entity/Q27683826
Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1Tricyclic GyrB/ParE (TriBE) inhibitors: a new class of broad-spectrum dual-targeting antibacterial agentsDiscovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.In vitro activity of novel gyrase inhibitors against a highly resistant population of Pseudomonas aeruginosaBiological evaluation of benzothiazole ethyl urea inhibitors of bacterial type II topoisomerases.New antibacterial agents: patent applications published in 2011.Molecular basis for the differential quinolone susceptibility of mycobacterial DNA gyrase.Targeting DNA Replication and Repair for the Development of Novel Therapeutics against Tuberculosis.Anticancer Properties of Halogenated Pyrrolo[3,2-d]pyrimidines with Decreased Toxicity via N5 Substitution.Design, synthesis, and biological evaluation of 1-ethyl-3-(thiazol-2-yl)urea derivatives as Escherichia coli DNA gyrase inhibitors.Synthesis and Evaluation of N-Phenylpyrrolamides as DNA Gyrase B Inhibitors.Design, Synthesis, and Evaluation of Novel Tyrosine-Based DNA Gyrase B Inhibitors.NMR structural characterization of the N-terminal active domain of the gyrase B subunit fromPseudomonas aeruginosaand its complex with an inhibitor
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Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Item
http://www.wikidata.org/entity/Q27683826
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2013 nî lūn-bûn
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2013 թուականի Մարտին հրատարակուած գիտական յօդուած
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2013 թվականի մարտին հրատարակված գիտական հոդված
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10.1016/J.BMCL.2012.11.032
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