Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin
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Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin.Direct interactions with the integrin β1 cytoplasmic tail activate the Abl2/Arg kinase.Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.Tyrosine phosphorylation of the Lyn Src homology 2 (SH2) domain modulates its binding affinity and specificity.The repeat region of cortactin is intrinsically disordered in solution.Regulated recruitment of SRGAP1 modulates RhoA signaling for contractility during epithelial junction maturation.
P2860
Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin
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2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2014 թվականի հուլիսին հրատարակված գիտական հոդված
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2014年の論文
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Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
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Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
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Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
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Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
@ast
Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
@en
Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
@nl
prefLabel
Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
@ast
Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
@en
Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
@nl
P2093
P2860
P356
P1476
Two Amino Acid Residues Confer ...... s for Phosphorylated Cortactin
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P2093
Anthony J Koleske
Christopher C Mader
Kazuya Machida
Stacey M Gifford
Tiffany L Halo
Titus J Boggon
Weizhi Liu
P2860
P304
P356
10.1074/JBC.M114.556480
P407
P577
2014-07-11T00:00:00Z