The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor
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Determination of potential scaffolds for human choline kinase α1 by chemical deconvolution studiesPharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1Plasmodium falciparum Choline Kinase Inhibition Leads to a Major Decrease in Phosphatidylethanolamine Causing Parasite DeathDNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions.A new family of choline kinase inhibitors with antiproliferative and antitumor activity derived from natural products.Choline kinase alpha-Putting the ChoK-hold on tumor metabolism.Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1)Harnessing allostery: a novel approach to drug discovery.Molecular mechanisms of asymmetric RAF dimer activation.New more polar symmetrical bipyridinic compounds: new strategy for the inhibition of choline kinase α1.Choline kinase inhibition induces exacerbated endoplasmic reticulum stress and triggers apoptosis via CHOP in cancer cells.Antiproliferative activity, cell cycle, and apoptosis studies of a series of 6-substituted 9H-purin-9-yl-pyridinium derivatives on a human cervical carcinoma cell line.A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2.Bacterial Thymidylate Synthase Binds Two Molecules of Substrate and Cofactor without Cooperativity.Hydration water and peptide dynamics--two sides of a coin. A neutron scattering and adiabatic calorimetry study at low hydration and cryogenic temperatures.Computationally driven drug discovery meeting-3 - Verona (Italy): 4 - 6th of March 2014.
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P2860
The mechanism of allosteric coupling in choline kinase α1 revealed by the action of a rationally designed inhibitor
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name
The mechanism of allosteric co ...... rationally designed inhibitor
@ast
The mechanism of allosteric co ...... rationally designed inhibitor
@en
The mechanism of allosteric co ...... rationally designed inhibitor
@nl
type
label
The mechanism of allosteric co ...... rationally designed inhibitor
@ast
The mechanism of allosteric co ...... rationally designed inhibitor
@en
The mechanism of allosteric co ...... rationally designed inhibitor
@nl
prefLabel
The mechanism of allosteric co ...... rationally designed inhibitor
@ast
The mechanism of allosteric co ...... rationally designed inhibitor
@en
The mechanism of allosteric co ...... rationally designed inhibitor
@nl
P2093
P2860
P50
P3181
P356
P1476
The mechanism of allosteric co ...... rationally designed inhibitor
@en
P2093
Adrián Velázquez-Campoy
Ana Conejo-García
Antonio Entrena
Antonio Espinosa
María Sahún-Roncero
P2860
P304
P3181
P356
10.1002/ANIE.201209660
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P577
2013-04-22T00:00:00Z