Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization - Wikidata - awgldk - TriplyDB

Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

http://www.wikidata.org/entity/Q27684133

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Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo Targeted regulation of PI3K/Akt/mTOR/NF-κB signaling by indole compounds and their derivatives: mechanistic details and biological implications for cancer therapy "Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Identification of dual kinase inhibitors of CK2 and GSK3β: combined qualitative and quantitative pharmacophore modeling approach.Potent and Selective CK2 Kinase Inhibitors with Effects on Wnt Pathway Signaling in Vivo.Exploring the Pivotal Role of the CK2 Hinge Region Sub-Pocket in Binding with Tricyclic Quinolone Analogues by Computational Analysis.A public-private partnership to unlock the untargeted kinome.

P2860

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P2860

Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

http://www.wikidata.org/entity/Q27684133

description

2012 nî lūn-bûn

@nan

2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

name

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@ast

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@en

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@nl

type

label

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@ast

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@en

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@nl

prefLabel

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@ast

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@en

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@nl

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P1433

ACS Medicinal Chemistry Letters

P1476

Potent and Selective Inhibitor ...... Structure-Guided Hybridization

@en

P2093

Allan Wu

http://www.w3.org/2001/XMLSchema#string

Bo Peng

http://www.w3.org/2001/XMLSchema#string

Christopher R Denz

http://www.w3.org/2001/XMLSchema#string

Claudio Chuaqui

http://www.w3.org/2001/XMLSchema#string

Daniel Russell

http://www.w3.org/2001/XMLSchema#string

Emma Cooke

http://www.w3.org/2001/XMLSchema#string

Hannah Pollard

http://www.w3.org/2001/XMLSchema#string

Huawei Chen

http://www.w3.org/2001/XMLSchema#string

James E Dowling

http://www.w3.org/2001/XMLSchema#string

John W Lee

http://www.w3.org/2001/XMLSchema#string

P2860

Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2

Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation

A quantitative analysis of kinase inhibitor selectivity

Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.

Ligand efficiency and fragment-based drug discovery.

Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.

Disruption of the regulatory beta subunit of protein kinase CK2 in mice leads to a cell-autonomous defect and early embryonic lethality

Protein kinase CK2: a challenge to canons.

The alpha catalytic subunit of protein kinase CK2 is required for mouse embryonic development

Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.

P304

278-83

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scholarly article

P356

10.1021/ML200257N

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4

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P478

3

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2012-04-12T00:00:00Z

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24900464

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P921

Aagianik kimischri

P932

4025639

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