A public-private partnership to unlock the untargeted kinome. - Wikidata - awgldk - TriplyDB

A public-private partnership to unlock the untargeted kinome.

A public-private partnership to unlock the untargeted kinome.

http://www.wikidata.org/entity/Q44090999

about

Ten things you should know about protein kinases: IUPHAR Review 14 Personalized cancer medicine: molecular diagnostics, predictive biomarkers, and drug resistance De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase Inhibitors The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.Seeding collaborations to advance kinase science with the GSK Published Kinase Inhibitor Set (PKIS)Polypharmacology in Precision Oncology: Current Applications and Future Prospects Identification of potent Yes1 kinase inhibitors using a library screening approach.Chemical interrogation of the malaria kinome.Playing well with others! Initiating and sustaining successful collaborations between industry, academia and government.Proteomics in cancer biomarkers discovery: challenges and applications.Identification of a Selective G1-Phase Benzimidazolone Inhibitor by a Senescence-Targeted Virtual Screen Using Artificial Neural Networks.Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets.Innovation in academic chemical screening: filling the gaps in chemical biology Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cells Assessing adaptation of the cancer kinome in response to targeted therapies.Going for broke: targeting the human cancer pseudokinome.Progress toward JAK1-selective inhibitors.c-Jun N-terminal kinase inhibitors: a patent review (2010 - 2014).Progress towards a public chemogenomic set for protein kinases and a call for contributions.Unprecedently Large-Scale Kinase Inhibitor Set Enabling the Accurate Prediction of Compound-Kinase Activities: A Way toward Selective Promiscuity by Design?Prediction of intracellular exposure bridges the gap between target- and cell-based drug discovery.Selective JAK3 Inhibitors with a Covalent Reversible Binding Mode Targeting a New Induced Fit Binding Pocket.Synthetic phosphorylation of p38α recapitulates protein kinase activity Integration of genomic, transcriptomic and functional profiles of aggressive osteosarcomas across multiple species.Design and synthesis of tricyclic JAK3 inhibitors with picomolar affinities as novel molecular probes.Synthesis of kinase inhibitors containing a pentafluorosulfanyl moiety.Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions.The target landscape of clinical kinase drugs.What is the future of bromodomains in targeted drug development?Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.1,2,6-Thiadiazinones as Novel Narrow Spectrum Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) Inhibitors.Effect of missing data on multitask prediction methods.Immuno-detection by sequencing enables large-scale high-dimensional phenotyping in cells.Probing questions

P2860

Q26849417-E0AA363E-F022-461B-81C5-43ED841A9ABA Q26866517-4676B74D-E8A5-4880-A373-B9B7A446174C Q27677088-11FF0BF5-3972-484C-B257-FDDAB054AF5E Q27680538-49BC87D8-D0F3-4CEE-9B98-97DEB1FBAE87 Q27681896-93E68E0E-5D09-4B22-9AC1-E73C8EF51880 Q28546672-A3141BFB-64DE-493E-B071-CB4AC61FD572 Q28603128-AA48B094-CE5C-4542-87D6-491E9117C152 Q28834261-79949036-EB40-49C0-B7B5-0F0A2259C517 Q30369189-EEEA9FCD-BFE0-4114-9FC9-EB4CC431F6B9 Q30486521-BA6253D8-B557-49BA-A24F-E342D98CA3E9 Q30846907-7628D60F-6881-4FEA-AFA6-D047B79EEBE7 Q31119738-B3788AC9-F862-48F7-9271-C7624A9826CB Q34541909-B79C7E2E-E5B8-4284-A408-AFB48525AEB9 Q35111663-EE1BB2FA-AD3D-4878-B5A4-44245F686770 Q35592114-28B65A4D-0712-4D8B-B90D-CC3078A7533B Q35811361-157073E9-942B-441B-8040-E7B2C0CD60C3 Q36346161-3C40BC2B-4AAE-47C8-97EB-F62FEAEEB08B Q37037229-F9638951-EFB2-459C-B0F8-BBEA721BA311 Q37641736-D3E315FC-332C-4BEF-A8D1-109FC9A95B5A Q38238603-8AE1DD3B-6129-4B9D-A7DD-D72400B06FC3 Q38307398-3F84A5C4-ADA6-4F74-8DF7-F0E0733EBB59 Q38357083-3612E25B-6697-4DD5-996D-390D73FA4DF0 Q38492604-9ACE53F4-1F83-4CC3-8CAF-487C6B36D357 Q38646648-E5972F03-11BA-4187-A70C-F6C55E5F57F5 Q39534317-1994F1B7-ADEA-42C2-876A-FC0D963BD99C Q41256404-D38A54E6-B6D6-4C60-9DBD-955725E5AA43 Q41835379-29010B1F-E029-4DFA-8A4D-0380119FF65D Q41889780-F4533D04-5FAE-4A95-A14F-B29572653B19 Q44077895-108B9B48-18C1-4DE4-9A44-432752FFADD7 Q45332740-4DFBFD22-6CA4-42AD-A779-8A5EA01E7D3E Q47116598-B1F37AA5-8B06-44CC-8DFE-00F56D2B4914 Q47252031-355DD30C-19DB-4C14-99FF-C596A8B5138E Q47345032-8056BBE3-DA9E-4F39-B738-84E94FEF4818 Q48808733-CDBA3121-55D4-4850-B557-ED12E90C946D Q54269966-F9C28D28-1693-41E4-9A42-6C48BBFD8CC0 Q54978646-7868C7F0-6D94-49A1-98E1-C0B48D93027C Q55085065-092A69B7-EC2B-48FA-A08B-04293DC0465C Q55188599-121A6C7A-9B5D-4099-B841-730745EB7E9E Q58884378-2E937E7A-1FAB-4931-B433-E8AE7FFD353A

P2860

A public-private partnership to unlock the untargeted kinome.

http://www.wikidata.org/entity/Q44090999

description

2013 nî lūn-bûn

@nan

2013年の論文

@ja

2013年学术文章

@wuu

2013年学术文章

@zh

2013年学术文章

@zh-cn

2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

@zh-sg

2013年學術文章

@yue

2013年學術文章

@zh-hant

name

A public-private partnership to unlock the untargeted kinome.

@en

A public-private partnership to unlock the untargeted kinome.

@nl

type

label

A public-private partnership to unlock the untargeted kinome.

@en

A public-private partnership to unlock the untargeted kinome.

@nl

prefLabel

A public-private partnership to unlock the untargeted kinome.

@en

A public-private partnership to unlock the untargeted kinome.

@nl

P1433

Q44090999-C5753D5A-063B-4007-904F-43C1D8ECB522

P1476

Q44090999-8CDB8F0D-E6ED-4E93-8339-32DDADB5376B

P2093

Q44090999-25771165-7CD3-4009-BFFC-4EE7D882E11B

Q44090999-25D785A7-6449-4674-BCFA-B75AFD7FC9AB

Q44090999-2A31099A-4888-4FA5-9DB7-0CCD4228C63B

Q44090999-2D4F632A-2DDA-4275-AEF3-975C83713B5C

Q44090999-300F5464-213B-48B0-994B-6BB0D0173095

Q44090999-885F5728-3BA2-4C22-A21C-B4C939E09D2A

Q44090999-BA439380-AEAE-4097-A1C8-40295E774542

Q44090999-DBFB4F49-3EEA-4B7A-8E8B-A97A5527ECA1

Q44090999-E0C17018-F836-4BA4-8FE8-D300C931D8FD

Q44090999-F5895365-B45A-4B05-8CCC-6CD9C2430F64

P2860

Q44090999-0966784F-88FA-4D5B-AF12-F0B7839AD299

Q44090999-0A630686-8815-4A82-95BA-B1905FC501A3

Q44090999-10D26301-F86B-47FD-B44E-CBDFE343C88D

Q44090999-24E5A2C2-F916-42A5-8B94-631FF755674C

Q44090999-27C3C801-4D27-41E3-AF36-0E2EB786DD31

Q44090999-2C156BB9-64D2-4598-9DE5-55851BC01138

Q44090999-395A8642-1255-40F7-B713-D9E12AB9E0ED

Q44090999-3EA30BA7-98E5-4D95-B108-6B819A15409E

Q44090999-500A8DD4-EDB9-47FE-BF7B-D24E985A0C98

Q44090999-5DF7DAB6-18B2-40DE-8C41-2A478EB63C6B

P2888

Q44090999-CFA195DA-6C77-4E12-83E6-7685E945872E

P304

Q44090999-0C246C8D-79FB-4F44-BA18-1996A114195A

P31

Q44090999-884962EB-7911-4228-BF26-66F0D094300B

P356

Q44090999-2194FAB7-B1AE-4E14-8227-95DA9D2AD07B

P433

Q44090999-82FDA970-DE79-49C5-BA60-5D0B43AAE95C

P478

Q44090999-66426903-B736-48DD-86C9-7AFA5D0A8F7B

P50

Q44090999-1853926F-218D-42F7-86AE-9BD3E7FD88E9

Q44090999-416AA125-66B2-4B5B-B7A7-243B8375051B

Q44090999-5969C4DE-2271-4CB2-B59D-2BABFC179A67

Q44090999-90E230B3-8741-4831-9420-E16DC83EF65C

Q44090999-A048B121-6749-44CF-A93E-106501C3BABD

Q44090999-E9A3CB13-BBFC-4CF0-827B-E64355479A0C

P577

Q44090999-74AACB99-FA1D-4FAF-9105-D252322EB490

P5875

Q44090999-6C40AF35-93B0-41F0-9C7D-7A929D79DE64

P698

Q44090999-DD5E9B5B-24F8-4942-B5DB-1C09BEBF4C5A

P921

Q44090999-BE5E15ED-A1DE-4B34-836E-B8BB9023A637

P356

P1433

Nature Chemical Biology

P1476

A public-private partnership to unlock the untargeted kinome.

@en

P2093

Doriano Fabbro

http://www.w3.org/2001/XMLSchema#string

Julian Blagg

http://www.w3.org/2001/XMLSchema#string

Karen E Lackey

http://www.w3.org/2001/XMLSchema#string

Nathanael S Gray

http://www.w3.org/2001/XMLSchema#string

Nicholas C O Tomkinson

http://www.w3.org/2001/XMLSchema#string

Paul Gillespie

http://www.w3.org/2001/XMLSchema#string

Paulo Arruda

http://www.w3.org/2001/XMLSchema#string

Paulo Mazzafera

http://www.w3.org/2001/XMLSchema#string

Timothy M Willson

http://www.w3.org/2001/XMLSchema#string

William J Zuercher

http://www.w3.org/2001/XMLSchema#string

P2860

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor

Discovery of Potent and Selective Covalent Inhibitors of JNK

A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation

Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization

Too many roads not taken

The case for open-access chemical biology. A strategy for pre-competitive medicinal chemistry to promote drug discovery

Comprehensive analysis of kinase inhibitor selectivity

P2888

P304

3-6

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NCHEMBIO.1113

http://www.w3.org/2001/XMLSchema#string

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

9

http://www.w3.org/2001/XMLSchema#string

P50

Bernhard Kuster

Stephen K Burley

P577

2013-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

233914313

http://www.w3.org/2001/XMLSchema#string

P698

23238671

http://www.w3.org/2001/XMLSchema#string

P921