Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors

Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors

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http://www.wikidata.org/entity/Q27684134
Novel 2,4-Diarylaminopyrimidine Analogues (DAAPalogues) Showing Potent c-Met/ALK Multikinase Inhibitory Activities.Therapeutic Potential of Spirooxindoles as Antiviral AgentsNovel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution.Tankyrases: structure, function and therapeutic implications in cancer.Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy.PARP inhibitors as antitumor agents: a patent update (2013-2015).Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone.Enantioselective Rh-Catalyzed Carboacylation of C═N Bonds via C-C Activation of Benzocyclobutenones.Contrasting sirtuin and poly(ADP-ribose)polymerase activities of selected 2,4,6-trisubstituted benzimidazoles.Acquired resistance of phosphatase and tensin homolog-deficient cells to poly(ADP-ribose) polymerase inhibitor and Ara-C mediated by 53BP1 loss and SAMHD1 overexpression.Active site fingerprinting and pharmacophore screening strategies for the identification of dual inhibitors of protein kinase C [Formula: see text] and poly (ADP-ribose) polymerase-1 (PARP-1).Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors.
P2860

Design, synthesis, and biological evaluation of a series of benzo[de][1,7]naphthyridin-7(8H)-ones bearing a functionalized longer chain appendage as novel PARP1 inhibitors

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http://www.wikidata.org/entity/Q27684134
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2013 nî lūn-bûn
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2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2013 թվականի ապրիլին հրատարակված գիտական հոդված
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2013年の論文
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年学术文章
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2013年學術文章
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name
Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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type
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Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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prefLabel
Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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Design, synthesis, and biologi ...... dage as novel PARP1 inhibitors
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P2093
P304
P31
P356
P407
P433
P478
P577
P5875
P698