A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo - Wikidata - awgldk - TriplyDB

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

http://www.wikidata.org/entity/Q27684428

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Subtle Dynamic Changes Accompany Hck Activation by HIV-1 Nef and are Reversed by an Antiretroviral Kinase Inhibitor.Engraftment of Human Primary Acute Myeloid Leukemia Defined by Integrated Genetic Profiling in NOD/SCID/IL2rγnull Mice for Preclinical Ceramide-Based Therapeutic Evaluation.NOD-scidIl2rg (tm1Wjl) and NOD-Rag1 (null) Il2rg (tm1Wjl) : a model for stromal cell-tumor cell interaction for human colon cancer Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression Promotion of Tumor Invasion by Tumor-Associated Macrophages: The Role of CSF-1-Activated Phosphatidylinositol 3 Kinase and Src Family Kinase Motility Signaling.Identification and targeting leukemia stem cells: The path to the cure for acute myeloid leukemia.Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition Cancer stem cells as a target population for drug discovery.Hematopoietic cell kinase (HCK) as a therapeutic target in immune and cancer cells.Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells.Src family kinases and their role in hematological malignancies.Targeting acute myeloid leukemia stem cells: a review and principles for the development of clinical trials.Relevance of leukemic stem cells in acute myeloid leukemia: heterogeneity and influence on disease monitoring, prognosis and treatment design.Aminoisoquinoline benzamides, FLT3 and Src-family kinase inhibitors, potently inhibit proliferation of acute myeloid leukemia cell lines.Neoplasms in the bone marrow niches: disturbance of the microecosystem.Stem cells: bad seeds.Are we ready to take full advantage of patient-derived tumor xenograft models?Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.Selective inhibition of the myeloid Src-family kinase Fgr potently suppresses AML cell growth in vitro and in vivo.Computer simulations of the signalling network in FLT3 +-acute myeloid leukaemia - indications for an optimal dosage of inhibitors against FLT3 and CDK6.Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.Respivert's multikinase inhibitors, an evaluation of WO2014033446 to WO2014033449.eModel-BDB: a database of comparative structure models of drug-target interactions from the Binding Database A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

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A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

http://www.wikidata.org/entity/Q27684428

description

2013 nî lūn-bûn

@nan

2013 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

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2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

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2013年论文

@wuu

name

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@ast

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@en

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@nl

type

label

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@ast

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@en

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@nl

prefLabel

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@ast

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@en

A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

@nl

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SCITRANSLMED.3004387

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Science Translational Medicine

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A pyrrolo-pyrimidine derivative targets human primary AML stem cells in vivo

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Akiko Kaneko

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Akiko Sone

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Akiko Tanaka

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Fumihiko Ishikawa

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Hiroshi Kajita

http://www.w3.org/2001/XMLSchema#string

Ikuko Ogahara

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Leonard D Shultz

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Mariko Tomizawa-Murasawa

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Mitsuo Kuratani

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Motoaki Wakiyama

http://www.w3.org/2001/XMLSchema#string

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Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells

Processing of X-ray diffraction data collected in oscillation mode

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

A novel Pim-1 kinase inhibitor targeting residues that bind the substrate peptide

Crystal structure of the Src family tyrosine kinase Hck

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.

Age-related risk profile and chemotherapy dose response in acute myeloid leukemia: a study by the German Acute Myeloid Leukemia Cooperative Group.

Coot: model-building tools for molecular graphics

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10.1126/SCITRANSLMED.3004387

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181

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5

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Mikako Shirouzu

Shigeyuki Yokoyama

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2013-04-17T00:00:00Z

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236214992

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23596204

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