Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor - Wikidata - awgldk - TriplyDB

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor

http://www.wikidata.org/entity/Q27685195

about

Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors Emergence of TNIK inhibitors in cancer therapeutics.Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase Inhibitors From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites.Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation.Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.Tankyrases: structure, function and therapeutic implications in cancer.Recent advances in the structure-based rational design of TNKSIs.The impact of binding thermodynamics on medicinal chemistry optimizations.The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling.LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.Targeting Tankyrase to Fight WNT-dependent Tumours.Molecular genetics and targeted therapy of WNT-related human diseases (Review).Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.WNT signalling in prostate cancer.Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review).Identification of Novel Target for Osteosarcoma by Network Analysis

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P2860

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor

http://www.wikidata.org/entity/Q27685195

description

2013 nî lūn-bûn

@nan

2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի օգոստոսին հրատարակված գիտական հոդված

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2013年の論文

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2013年学术文章

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2013年学术文章

@zh-cn

2013年学术文章

@zh-hans

2013年学术文章

@zh-my

2013年学术文章

@zh-sg

2013年學術文章

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name

Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

@ast

Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

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Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

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type

label

Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

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Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

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Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

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prefLabel

Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

@ast

Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

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Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

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P1433

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P1433

Journal of Medicinal Chemistry

P1476

Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor

@en

P2093

Aleem Fazal

http://www.w3.org/2001/XMLSchema#string

Atwood K Cheung

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B Barry Touré

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Bharat Lagu

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Brant Firestone

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Christina A Kirby

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Christine Hiu-Tung Chen

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Donovan N Chin

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Dyuti Majumdar

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Etienne Ochala

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P304

6495-6511

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scholarly article

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10.1021/JM400807N

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16

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56

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Nigel J. Waters

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2013-08-13T00:00:00Z

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23844574

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