Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor
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Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicinepara-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitorsEmergence of TNIK inhibitors in cancer therapeutics.Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Fragment-Based Drug Design of Novel Pyranopyridones as Cell Active and Orally Bioavailable Tankyrase InhibitorsFrom Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites.Identification of a new class of WNT1 inhibitor: Cancer cells migration, G-quadruplex stabilization and target validation.Heart regeneration: opportunities and challenges for drug discovery with novel chemical and therapeutic methods or agents.Tankyrases: structure, function and therapeutic implications in cancer.Recent advances in the structure-based rational design of TNKSIs.The impact of binding thermodynamics on medicinal chemistry optimizations.The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation.Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling.LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.Targeting Tankyrase to Fight WNT-dependent Tumours.Molecular genetics and targeted therapy of WNT-related human diseases (Review).Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.WNT signalling in prostate cancer.Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review).Identification of Novel Target for Osteosarcoma by Network Analysis
P2860
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P2860
Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor
description
2013 nî lūn-bûn
@nan
2013 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
name
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@ast
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@en
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@nl
type
label
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@ast
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@en
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@nl
prefLabel
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@ast
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@en
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@nl
P2093
P356
P1476
Identification of NVP-TNKS656: ...... lly active tankyrase inhibitor
@en
P2093
Aleem Fazal
Atwood K Cheung
B Barry Touré
Bharat Lagu
Brant Firestone
Christina A Kirby
Christine Hiu-Tung Chen
Donovan N Chin
Dyuti Majumdar
Etienne Ochala
P304
P356
10.1021/JM400807N
P407
P577
2013-08-13T00:00:00Z