Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Item
http://www.wikidata.org/entity/Q27685406
Oxabicyclooctane-Linked Novel Bacterial Topoisomerase Inhibitors as Broad Spectrum Antibacterial AgentsThiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyraseDevelopment of EBV-encoded small RNA targeted PCR to classify EBV positive diffuse large B-cell lymphoma (DLBCL) of the elderly.New Structural Templates for Clinically Validated and Novel Targets in Antimicrobial Drug Research and Development.In Vitro and In Vivo Characterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase.NBTI 5463 is a novel bacterial type II topoisomerase inhibitor with activity against gram-negative bacteria and in vivo efficacy.Novel Bacterial Topoisomerase Inhibitors with Potent Broad-Spectrum Activity against Drug-Resistant Bacteria.Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii.Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.Insights into the mechanism of inhibition of novel bacterial topoisomerase inhibitors from characterization of resistant mutants of Staphylococcus aureus.Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor.Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site.DNA Topoisomerases as Targets for Antibacterial Agents.Topoisomerases as anticancer targets.A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.
P2860

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Item
http://www.wikidata.org/entity/Q27685406
description
2013 nî lūn-bûn
@nan
2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
name
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@ast
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@en
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@nl
type
label
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@ast
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@en
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@nl
prefLabel
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@ast
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@en
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@nl
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P356
P1433
P1476
Novel hydroxyl tricyclics (e.g ...... terial type IIA topoisomerases
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2013.07.013
P407
P433
P478
P50
P577
P5875
P698