Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins
about
Selectivity by small-molecule inhibitors of protein interactions can be driven by protein surface fluctuations3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.DARC: Mapping Surface Topography by Ray-Casting for Effective Virtual Screening at Protein Interaction Sites.Structural Re-engineering of the α-Helix Mimetic JY-1-106 into Small Molecules: Disruption of the Mcl-1-Bak-BH3 Protein-Protein Interaction with 2,6-Di-Substituted Nicotinates"Old Dogs with New Tricks": exploiting alternative mechanisms of action and new drug design strategies for clinically validated HIV targets.Small molecule Mcl-1 inhibitors for the treatment of cancer.New dimension in therapeutic targeting of BCL-2 family proteins.Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer.An overview of molecular hybrids in drug discovery.A hybrid of thiazolidinone with the hydroxamate scaffold for developing novel histone deacetylase inhibitors with antitumor activities.Mcl-1 inhibitors: a patent review.Development of 3-phenyl-N-(2-(3-phenylureido)ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins.Enrichment of druggable conformations from apo protein structures using cosolvent-accelerated molecular dynamicsDesigned BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.'Borono-lectin' based engineering as a versatile platform for biomedical applications.HSA IIA subdomain-based developing anticancer metal prodrug: a new and improved approach.Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain.In silico approaches to identify novel myeloid cell leukemia-1 (Mcl-1) inhibitors for treatment of cancer.
P2860
Q28543593-931C354D-85D1-4838-8FDC-0B2D19BCCBD1Q33662495-0FE5AC22-E422-45F7-B932-27BA0128A786Q34450265-E8A4D2AE-02BC-41A8-96F4-0C739AB3944CQ35876252-66BF9B81-5264-41F4-8351-62F44BD1ED28Q35981250-91096232-6B12-4BF3-B997-D98468F71085Q36447801-06D393A7-3BDF-49D8-825A-6C7C96C19B87Q36818334-11A470C3-EF9A-4FCE-9AAE-442506682210Q38212854-E5BBF5FA-04B4-416E-81E4-24D12748C815Q38244767-60661864-9F80-4E27-8B65-53477EDA8F2BQ38477617-B4BCAB2F-76CE-4E20-9C49-D7ECD2772A7BQ38563530-7F367456-AD29-429B-8691-D0CD5D3B586CQ38685830-FACA9C13-7CD5-4615-A6CA-B81E235EDC9DQ38806404-4AD0887F-6A29-4344-97D2-78AADB487E17Q38981785-FACA33EC-35D3-41A0-BD77-0BE478F156DCQ39000123-AE69676E-1775-4A02-9B65-23A097AA950FQ41023300-0E1857C4-BB54-49D2-B8A5-EBD6206E73BAQ42906307-A4FFC538-3973-44B6-B5BC-89A4A1B81F75Q47131624-267BB854-DBF3-4973-B480-A59D42ECBE60Q48235169-535A9266-01CB-4E9B-826D-D09FE74FB6DFQ51308516-23EFD7D5-364D-4A8E-AF8D-AF77F09C43E7Q51533605-916812F4-D33A-4845-8308-CC407695E1EFQ53159453-9F19EB06-7FF6-4481-B88D-0E0F5C169D75
P2860
Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins
description
2013 nî lūn-bûn
@nan
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@ast
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@en
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@nl
type
label
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@ast
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@en
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@nl
prefLabel
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@ast
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@en
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@nl
P2093
P356
P1476
Discovery of potent Mcl-1/Bcl- ...... al analysis of target proteins
@en
P2093
Goushi Nishida
Ikuo Miyahisa
Katsuji Aikawa
Masakazu Inazuka
Michiko Tawada
Misaki Homma
Satoshi Sogabe
Shigeru Igaki
Tomohiro Kawamoto
P304
P356
10.1021/JM401170C
P407
P577
2013-12-12T00:00:00Z