Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
about
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based designThe functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins.Selective peptide inhibitors of antiapoptotic cellular and viral Bcl-2 proteins lead to cytochrome c release during latent Kaposi's sarcoma-associated herpesvirus infection.Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.Tumor-targeting peptides from combinatorial libraries.Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity.BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer.MUC1-C Stabilizes MCL-1 in the Oxidative Stress Response of Triple-Negative Breast Cancer Cells to BCL-2 Inhibitors.Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics.BH3 profiling and a toolkit of BH3-mimetic drugs predict anti-apoptotic dependence of cancer cells.Designing helical peptide inhibitors of protein-protein interactionsBruton's tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia.A transgenic mouse model to inducibly target prosurvival Bcl2 proteins with selective BH3 peptides in vivo.Why do BCL-2 inhibitors work and where should we use them in the clinic?Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors.Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.PixelDB: Protein-peptide complexes annotated with structural conservation of the peptide binding mode.Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling.Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
P2860
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P2860
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
@en
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
@nl
type
label
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
@en
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
@nl
prefLabel
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
@en
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
@nl
P2860
P50
P356
P1433
P1476
Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells
@en
P2093
Anthony Letai
Stefano V Gullá
P2860
P304
P356
10.1021/CB500340W
P577
2014-07-23T00:00:00Z