Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface - Wikidata - awgldk - TriplyDB

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

http://www.wikidata.org/entity/Q27688974

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Engineered IgG1-Fc--one fragment to bind them all Bispecific antibodies and their applications Dual anti-idiotypic purification of a novel, native-format biparatopic anti-MET antibody with improved in vitro and in vivo efficacy.Immunoglobulin Fc Heterodimer Platform Technology: From Design to Applications in Therapeutic Antibodies and Proteins The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy Advances in Antibody Design CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.comets (Constrained Optimization of Multistate Energies by Tree Search): A Provable and Efficient Protein Design Algorithm to Optimize Binding Affinity and Specificity with Respect to Sequence.Antibody H3 Structure Prediction.Inferring the microscopic surface energy of protein-protein interfaces from mutation data.Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies.Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds.Exploiting light chains for the scalable generation and platform purification of native human bispecific IgG.A novel antibody engineering strategy for making monovalent bispecific heterodimeric IgG antibodies by electrostatic steering mechanism.Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry.Improving target cell specificity using a novel monovalent bispecific IgG design Fab-based bispecific antibody formats with robust biophysical properties and biological activity A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization.Computationally Designed Bispecific Antibodies using Negative State Repertoires.A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets Protocols for Molecular Modeling with Rosetta3 and RosettaScripts Tumor-penetrating peptide fused EGFR single-domain antibody enhances cancer drug penetration into 3D multicellular spheroids and facilitates effective gastric cancer therapy.Cross-arm binding efficiency of an EGFR x c-Met bispecific antibody.Synergistic Neutralization of Pertussis Toxin by a Bispecific Antibody In Vitro and In Vivo Molecular signatures of mu opioid receptor and somatostatin receptor 2 in pancreatic cancer.Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.Recent developments in antibody-based assays for the detection of bacterial toxins.The development of therapeutic monoclonal antibodies: overview of the nonclinical safety assessment.A Tri-part Protein Complementation System Using Antibody-Small Peptide Fusions Enables Homogeneous Immunoassays.The impact of structural biology in medicine illustrated with four case studies.Algorithms for protein design.Sphinx: merging knowledge-based and ab initio approaches to improve protein loop prediction.The use of CrossMAb technology for the generation of bi- and multispecific antibodies.Comparing domain interactions within antibody Fabs with kappa and lambda light chains.Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system.Production of bispecific antibodies in "knobs-into-holes" using a cell-free expression system An efficient route to bispecific antibody production using single-reactor mammalian co-culture.Novel multispecific heterodimeric antibody format allowing modular assembly of variable domain fragments.Protein design of IgG/TCR chimeras for the co-expression of Fab-like moieties within bispecific antibodies.

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P2860

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

http://www.wikidata.org/entity/Q27688974

description

2014 nî lūn-bûn

@nan

2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

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name

Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Generation of bispecific IgG a ...... of an orthogonal Fab interface

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Nature Biotechnology

P1476

Generation of bispecific IgG a ...... of an orthogonal Fab interface

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P2093

Aaron K Chamberlain

http://www.w3.org/2001/XMLSchema#string

Anna Pustilnik

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Arlene Sereno

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Carolyn Ho

http://www.w3.org/2001/XMLSchema#string

Christophe Hansen-Estruch

http://www.w3.org/2001/XMLSchema#string

Elaine M Conner

http://www.w3.org/2001/XMLSchema#string

Eric M Smith

http://www.w3.org/2001/XMLSchema#string

Flora Huang

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Gurkan Guntas

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Heather L Rick

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P2860

Predicting protein structures with a multiplayer online game

Computational redesign of endonuclease DNA binding and cleavage specificity

Bispecific antibodies for cancer therapy: the light at the end of the tunnel?

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for Dimerization

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair

Phasercrystallographic software

Refinement of macromolecular structures by the maximum-likelihood method

P2888

P304

191-8

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scholarly article

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1330474

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10.1038/NBT.2797

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2

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32

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Andrew Leaver-Fay

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2014-02-01T00:00:00Z

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1004967150

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24463572

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