Improving target cell specificity using a novel monovalent bispecific IgG design - Wikidata - awgldk - TriplyDB

Improving target cell specificity using a novel monovalent bispecific IgG design

Improving target cell specificity using a novel monovalent bispecific IgG design

http://www.wikidata.org/entity/Q36213090

about

CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.Fc Engineering for Developing Therapeutic Bispecific Antibodies and Novel Scaffolds.Enhancement of Immune Effector Functions by Modulating IgG's Intrinsic Affinity for Target Antigen Fab-based bispecific antibody formats with robust biophysical properties and biological activity Computationally Designed Bispecific Antibodies using Negative State Repertoires.A Modeling and Experimental Investigation of the Effects of Antigen Density, Binding Affinity, and Antigen Expression Ratio on Bispecific Antibody Binding to Cell Surface Targets Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies.The use of CrossMAb technology for the generation of bi- and multispecific antibodies.Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion.The application of mathematical modelling to the design of bispecific monoclonal antibodies.Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence.Structural basis of a novel heterodimeric Fc for bispecific antibody production.Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry.Insights into the molecular basis of a bispecific antibody's target selectivity.The making of bispecific antibodies Balancing Selectivity and Efficacy of Bispecific Epidermal Growth Factor Receptor (EGFR) × c-MET Antibodies and Antibody-Drug Conjugates.Computational design of a specific heavy chain/κ light chain interface for expressing fully IgG bispecific antibodies.Tethered-variable CL bispecific IgG: an antibody platform for rapid bispecific antibody screening.Novel CH1:CL interfaces that enhance correct light chain pairing in heterodimeric bispecific antibodies.Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies.Purification of common light chain IgG-like bispecific antibodies using highly linear pH gradients.Guiding bispecific monovalent antibody formation through proteolysis of IgG1 single-chain.DNA damaging agent-based antibody-drug conjugates for cancer therapy Expanding the Boundaries of Biotherapeutics with Bispecific Antibodies

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P2860

Improving target cell specificity using a novel monovalent bispecific IgG design

http://www.wikidata.org/entity/Q36213090

description

2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

2015年论文

@zh

2015年论文

@zh-cn

name

Improving target cell specificity using a novel monovalent bispecific IgG design

@ast

Improving target cell specificity using a novel monovalent bispecific IgG design

@en

type

label

Improving target cell specificity using a novel monovalent bispecific IgG design

@ast

Improving target cell specificity using a novel monovalent bispecific IgG design

@en

prefLabel

Improving target cell specificity using a novel monovalent bispecific IgG design

@ast

Improving target cell specificity using a novel monovalent bispecific IgG design

@en

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19420862.2015.1007816

P1433

Monoclonal Antibodies

P1476

Improving target cell specificity using a novel monovalent bispecific IgG design

@en

P2093

Anna Hansen

http://www.w3.org/2001/XMLSchema#string

Chunning Yang

http://www.w3.org/2001/XMLSchema#string

Dhanesh V Gadre

http://www.w3.org/2001/XMLSchema#string

Herren Wu

http://www.w3.org/2001/XMLSchema#string

Hongji Liu

http://www.w3.org/2001/XMLSchema#string

Jihong Wang

http://www.w3.org/2001/XMLSchema#string

Kris Sachsenmeier

http://www.w3.org/2001/XMLSchema#string

Marcia Carlson

http://www.w3.org/2001/XMLSchema#string

Martin Jack Borrok

http://www.w3.org/2001/XMLSchema#string

Partha Sarathi Chowdhury

http://www.w3.org/2001/XMLSchema#string

P2860

Improved methods for building protein models in electron density maps and the location of errors in these models

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site

Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair

Generation of bispecific IgG antibodies by structure-based design of an orthogonal Fab interface

REFMAC5 for the refinement of macromolecular crystal structures

Phasercrystallographic software

The CCP4 suite: programs for protein crystallography

An efficient route to human bispecific IgG.

P304

377-389

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scholarly article

P356

10.1080/19420862.2015.1007816

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2

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7

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Vaheh Oganesyan

P577

2015-01-01T00:00:00Z

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271534935

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