Structural basis of microtubule stabilization by laulimalide and peloruside A - Wikidata - awgldk - TriplyDB

Structural basis of microtubule stabilization by laulimalide and peloruside A

Structural basis of microtubule stabilization by laulimalide and peloruside A

http://www.wikidata.org/entity/Q27689025

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Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option?Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery Structural Insights into the Pharmacophore of Vinca Domain Inhibitors of Microtubules Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis Pre-clinical evaluation of a novel class of anti-cancer agents, the Pyrrolo-1, 5-benzoxazepines Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments.Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.A previously undescribed tubulin binder Conformation-activity relationships of polyketide natural products.Structures of potent anticancer compounds bound to tubulin Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule 2-(m-Azidobenzoyl)taxol binds differentially to distinct β-tubulin isotypes Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures Synthetic, semisynthetic and natural analogues of peloruside A.Control of microtubule organization and dynamics: two ends in the limelight.Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy.Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis.Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration.Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.Challenges and opportunities in the high-resolution cryo-EM visualization of microtubules and their binding partners.Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease.Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.Microtubule-stabilizing properties of the avocado-derived toxins (+)-(R)-persin and (+)-(R)-tetrahydropersin in cancer cells and activity of related synthetic analogs.Mass spec studio for integrative structural biology.(-)-Rhazinilam and the diphenylpyridazinone NSC 613241: Two compounds inducing the formation of morphologically similar tubulin spirals but binding apparently to two distinct sites on tubulin.Taxol®: The First Microtubule Stabilizing Agent.Analysis of the binding mode of laulimalide to microtubules: Establishing a laulimalide-tubulin pharmacophore.Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β-Tubulin.Structure-based approaches for the design of benzimidazole-2-carbamate derivatives as tubulin polymerization inhibitors.Elucidating the mechanism of action of the clinically approved taxanes: a comprehensive comparison of local and allosteric effects.The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin.Structure based drug design and in vitro metabolism study: Discovery of N-(4-methylthiophenyl)-N,2-dimethyl-cyclopenta[d]pyrimidine as a potent microtubule targeting agent.Peloruside A, a microtubule-stabilizing agent, induces aneuploidy in ovarian cancer cells.Inhibition of human vascular endothelial cell migration and capillary-like tube formation by the microtubule-stabilizing agent peloruside A.Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells.Drug–tubulin interactions interrogated by transient absorption spectroscopy

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Structural basis of microtubule stabilization by laulimalide and peloruside A

http://www.wikidata.org/entity/Q27689025

description

2014 nî lūn-bûn

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2014 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2014 թվականի փետրվարին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Structural basis of microtubule stabilization by laulimalide and peloruside A

@ast

Structural basis of microtubule stabilization by laulimalide and peloruside A

@en

Structural basis of microtubule stabilization by laulimalide and peloruside A

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type

label

Structural basis of microtubule stabilization by laulimalide and peloruside A

@ast

Structural basis of microtubule stabilization by laulimalide and peloruside A

@en

Structural basis of microtubule stabilization by laulimalide and peloruside A

@nl

prefLabel

Structural basis of microtubule stabilization by laulimalide and peloruside A

@ast

Structural basis of microtubule stabilization by laulimalide and peloruside A

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Structural basis of microtubule stabilization by laulimalide and peloruside A

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Angewandte Chemie International Edition

P1476

Structural basis of microtubule stabilization by laulimalide and peloruside A

@en

P2093

Andrea E Prota

http://www.w3.org/2001/XMLSchema#string

John H Miller

http://www.w3.org/2001/XMLSchema#string

José Fernando Díaz

http://www.w3.org/2001/XMLSchema#string

Karl-Heinz Altmann

http://www.w3.org/2001/XMLSchema#string

Katja Bargsten

http://www.w3.org/2001/XMLSchema#string

Peter T Northcote

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P2860

Refined structure of alpha beta-tubulin at 3.5 A resolution

Template-free 13-protofilament microtubule–MAP assembly visualized at 8 Å resolution

A designed ankyrin repeat protein selected to bind to tubulin caps the microtubule plus end

A TOG: -tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

Molecular mechanism of action of microtubule-stabilizing anticancer agents

Microtubule-binding agents: a dynamic field of cancer therapeutics.

Structure of the alpha beta tubulin dimer by electron crystallography

High-resolution model of the microtubule

Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.

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1621-5

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scholarly article

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4103791

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10.1002/ANIE.201307749

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P433

6

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53

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Michel O Steinmetz

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2014-02-03T00:00:00Z

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24470331

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