Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

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http://www.wikidata.org/entity/Q27702294
Synthesis, structure-activity relationships and biological evaluation of 7-phenyl-pyrroloquinolinone 3-amide derivatives as potent antimitotic agents.Quinolin-6-Yloxyacetamides Are Microtubule Destabilizing Agents That Bind to the Colchicine Site of Tubulin.Non-kinase targets of protein kinase inhibitors.Identification of pyrrolopyrimidine derivative PP-13 as a novel microtubule-destabilizing agent with promising anticancer propertiesTargeting tubulin polymerization by novel 7-aryl-pyrroloquinolinones: Synthesis, biological activity and SARs.50 years of The FEBS Journal: looking back as well as ahead.Tubulin inhibitors targeting the colchicine binding site: a perspective of privileged structures.Effects of the Protonation State of Titratable Residues and the Presence of Water Molecules on Nocodazole Binding to β-Tubulin.Structure-based approaches for the design of benzimidazole-2-carbamate derivatives as tubulin polymerization inhibitors.Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy.Biological Evaluation in Vitro and in Silico of Azetidin-2-one Derivatives as Potential Anticancer Agents.High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo.Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus FS508
P2860

Structures of a diverse set of colchicine binding site inhibitors in complex with tubulin provide a rationale for drug discovery

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http://www.wikidata.org/entity/Q27702294
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2016 nî lūn-bûn
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2016 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2016 թվականի հունվարին հրատարակված գիտական հոդված
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2016年の論文
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2016年論文
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2016年論文
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2016年論文
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2016年論文
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2016年論文
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2016年论文
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Structures of a diverse set of ...... a rationale for drug discovery
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Structures of a diverse set of ...... a rationale for drug discovery
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Structures of a diverse set of ...... a rationale for drug discovery
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Structures of a diverse set of ...... a rationale for drug discovery
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Structures of a diverse set of ...... a rationale for drug discovery
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Structures of a diverse set of ...... a rationale for drug discovery
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Structures of a diverse set of ...... a rationale for drug discovery
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