about
Substrate specificity of the ubiquitin and Ubl proteasesThe business of deubiquitination - location, location, locationFunctional Amyloid Signaling via the Inflammasome, Necrosome, and Signalosome: New Therapeutic Targets in Heart FailureThe Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and RepairThe DenA/DEN1 Interacting Phosphatase DipA Controls Septa Positioning and Phosphorylation-Dependent Stability of Cytoplasmatic DenA/DEN1 during Fungal DevelopmentCullin-RING ubiquitin E3 ligase regulation by the COP9 signalosomeDisassembly of Lys11 and mixed linkage polyubiquitin conjugates provides insights into function of proteasomal deubiquitinases Rpn11 and Ubp6.Ubiquitylation, neddylation and the DNA damage responseCSNAP Is a Stoichiometric Subunit of the COP9 SignalosomeERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer DevelopmentStructural and biochemical characterization of the Cop9 signalosome CSN5/CSN6 heterodimerThe Evolution of COP9 Signalosome in Unicellular and Multicellular OrganismsThe CSN/COP9 signalosome regulates synaptonemal complex assembly during meiotic prophase I of Caenorhabditis elegans.The Arabidopsis Cop9 signalosome subunit 4 (CNS4) is involved in adventitious root formationStructural characterization of As-MIF and hJAB1 during the inhibition of cell-cycle regulation.Protein neddylation: beyond cullin-RING ligases.Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Structure of mammalian eIF3 in the context of the 43S preinitiation complex.CSN6 drives carcinogenesis by positively regulating Myc stability.Base-CP proteasome can serve as a platform for stepwise lid formationThe COP9 signalosome and cullin-RING ligases in the heartThe COP9 signalosome is vital for timely repair of DNA double-strand breaks.Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5.Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.A Single α Helix Drives Extensive Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly.Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia.Analysis of RNA expression of normal and cancer tissues reveals high correlation of COP9 gene expression with respiratory chain complex components.Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.Tackling the crystallographic structure determination of the COP9 signalosome.Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa.Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle.COPS5 amplification and overexpression confers tamoxifen-resistance in ERα-positive breast cancer by degradation of NCoR.Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion.Dynamics of an Active-Site Flap Contributes to Catalysis in a JAMM Family Metallo Deubiquitinase.Targeted inhibition of the COP9 signalosome for treatment of cancerThe putative oncotarget CSN5 controls a transcription-uncorrelated p53-mediated autophagy implicated in cancer cell survival under curcumin treatmentInhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo.Moonlighting and pleiotropy within two regulators of the degradation machinery: the proteasome lid and the CSN.Diversity of COP9 signalosome structures and functional consequences.
P2860
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P2860
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Crystal structure of the human COP9 signalosome
@ast
Crystal structure of the human COP9 signalosome
@en
Crystal structure of the human COP9 signalosome
@nl
type
label
Crystal structure of the human COP9 signalosome
@ast
Crystal structure of the human COP9 signalosome
@en
Crystal structure of the human COP9 signalosome
@nl
prefLabel
Crystal structure of the human COP9 signalosome
@ast
Crystal structure of the human COP9 signalosome
@en
Crystal structure of the human COP9 signalosome
@nl
P2093
P2860
P3181
P356
P1433
P1476
Crystal structure of the human COP9 signalosome
@en
P2093
Daniel Hess
Gondichatnahalli M Lingaraju
Martin Renatus
Nicolas H Thomä
Simone Cavadini
Ulrich Hassiepen
P2860
P2888
P304
P3181
P356
10.1038/NATURE13566
P407
P577
2014-08-14T00:00:00Z
P6179
1030186519