about
The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activationStructure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomideCrystal structure of the human COP9 signalosomeStructural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligaseCullin-RING ubiquitin E3 ligase regulation by the COP9 signalosomeFunctional regulation of the DNA damage-recognition factor DDB2 by ubiquitination and interaction with xeroderma pigmentosum group C protein.SPLINTS: small-molecule protein ligand interface stabilizers.Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase.ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors.A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndromeTargeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell modelsPlasticity in binding confers selectivity in ligand-induced protein degradationGenome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activityStructural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutationsTubulin Resists Degradation by Cereblon-Recruiting PROTACsThe CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin KTargeted protein degradation as a powerful research tool in basic biology and drug target discovery
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P50
description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Eric S. Fischer
@ast
Eric S. Fischer
@en
Eric S. Fischer
@es
Eric S. Fischer
@nl
Eric S. Fischer
@sl
type
label
Eric S. Fischer
@ast
Eric S. Fischer
@en
Eric S. Fischer
@es
Eric S. Fischer
@nl
Eric S. Fischer
@sl
prefLabel
Eric S. Fischer
@ast
Eric S. Fischer
@en
Eric S. Fischer
@es
Eric S. Fischer
@nl
Eric S. Fischer
@sl
P106
P1153
52463561100
P21
P31
P496
0000-0001-7337-6306