Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers - Wikidata - awgldk - TriplyDB

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

http://www.wikidata.org/entity/Q27694832

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Mitochondrial apoptosis and BH3 mimetics Minimalist Model Systems Reveal Similarities and Differences between Membrane Interaction Modes of MCL1 and BAK Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains.Assembling the puzzle: Oligomerization of α-pore forming proteins in membranes Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane Mitochondria and apoptosis: emerging concepts.Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling.An interconnected hierarchical model of cell death regulation by the BCL-2 family Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells.Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.Impact of loss of BH3-only proteins on the development and treatment of MLL-fusion gene-driven AML in mice.Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.Emerging understanding of Bcl-2 biology: Implications for neoplastic progression and treatment.Discoveries and controversies in BCL-2 protein-mediated apoptosis.The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane.Mitochondria-Judges and Executioners of Cell Death Sentences.Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins.Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis.Disordered clusters of Bak dimers rupture mitochondria during apoptosis.Bax and Bak Pores: Are We Closing the Circle?Dying to protect: cell death and the control of T-cell homeostasis.Pore formation by dimeric Bak and Bax: an unusual pore?Crystal structure of Bax bound to the BH3 peptide of Bim identifies important contacts for interaction.Structural model of active Bax at the membrane.Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains.MOMP, cell suicide as a BCL-2 family business.BCL-2 family proteins: changing partners in the dance towards death.The BCL-2 arbiters of apoptosis and their growing role as cancer targets.Bax, Bak and beyond - mitochondrial performance in apoptosis.Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.DIDS inhibits overexpression BAK1-induced mitochondrial apoptosis through GSK3β/β-catenin signaling pathway.BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove.Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells.Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.

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P2860

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

http://www.wikidata.org/entity/Q27694832

description

2014 nî lūn-bûn

@nan

2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

@zh-hk

2014年論文

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2014年論文

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2014年论文

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name

Bak core and latch domains sep ...... ains form symmetric homodimers

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Bak core and latch domains sep ...... ains form symmetric homodimers

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Bak core and latch domains sep ...... ains form symmetric homodimers

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type

label

Bak core and latch domains sep ...... ains form symmetric homodimers

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Bak core and latch domains sep ...... ains form symmetric homodimers

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Bak core and latch domains sep ...... ains form symmetric homodimers

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prefLabel

Bak core and latch domains sep ...... ains form symmetric homodimers

@ast

Bak core and latch domains sep ...... ains form symmetric homodimers

@en

Bak core and latch domains sep ...... ains form symmetric homodimers

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J.MOLCEL.2014.07.016

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Bak core and latch domains sep ...... ains form symmetric homodimers

@en

P2093

Adeline Y Robin

http://www.w3.org/2001/XMLSchema#string

Dana Westphal

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Geoff V Thompson

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Grant Dewson

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Jason M Brouwer

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Peter E Czabotar

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Peter M Colman

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Ray Bartolo

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938-46

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scholarly article

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1412817

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10.1016/J.MOLCEL.2014.07.016

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6

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55

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2014-09-18T00:00:00Z

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265255991

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25175025

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